Browsing Brage by Author "Haugen, Fred"
Now showing items 1-9 of 9
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A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Peer reviewed; Journal article, 2020)Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ... -
Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons
Zosen, Denis; Kondratskaya, Elena; Kaplan Arabaci, Öyküm; Haugen, Fred; Paulsen, Ragnhild Elisabeth Heimtun (Peer reviewed; Journal article, 2023)Antidepressants are used to treat depression and some anxiety disorders, including use in pregnant patients. The pharmacological actions of these drugs generally determine the uptake and metabolism of a series of ... -
Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests. A small scale study
Hansen, Kristine Eraker Aasland; Hudecova, Alexandra Misci; Haugen, Fred; Skjerve, Eystein; Ropstad, Erik; Zimmer, Karin Elisabeth (Peer reviewed; Journal article, 2022)BACKGROUND All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J, ... -
Experimental Models for Cold Exposure of Muscle in vitro and in vivo
Schjølberg, Tiril; Asoawe, Lucia; Krapf, Solveig Astrid; Rustan, Arild Christian; Thoresen, G. Hege; Haugen, Fred (Peer reviewed; Journal article, 2022)Work in cold environments may have a significant impact on occupational health. In these and similar situations, cold exposure localized to the extremities may reduce the temperature of underlying tissues. To investigate ... -
Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes
Skagen, Christine; Løvsletten, Nils Gunnar; Asoawe, Lucia; Al-Karbawi, Zeineb; Rustan, Arild Christian; Thoresen, G. Hege; Haugen, Fred (Peer reviewed; Journal article, 2023)Transient potential (TRP) ion channels expressed in primary sensory neurons act as the initial detectors of environmental cold and heat, information which controls muscle energy expenditure. We hypothesize that non-neuronal ... -
MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation
Moen, Aurora Lie; Jacobsen, Daniel; Phuyal, Santosh; Legfeldt, Anna; Haugen, Fred; Røe, Cecilie; Gjerstad, Johannes (Peer reviewed; Journal article, 2017) -
Novel methods for cold exposure of skeletal muscle in vivo and in vitro show temperature-dependent myokine production
Krapf, Solveig Astrid; Schjølberg, Tiril; Asoawe, Lucia; Honkanen, Susanna Kyllikki; Kase, Eili Tranheim; Thoresen, G. Hege; Haugen, Fred (Peer reviewed; Journal article, 2021)Proteins secreted from skeletal muscle serving a signalling role have been termed myokines. Many of the myokines are exercise factors, produced and released in response to muscle activity. Cold exposures affecting muscle ... -
Paracetamol perturbs neuronal arborization and disrupts the cytoskeletal proteins SPTBN1 and TUBB3 in both human and chicken in vitro models
Labba, Nils-Anders Johannes; Wæhler, Hallvard Austin; Houdaifi, Nora; Zosen, Denis; Haugen, Fred; Paulsen, Ragnhild Elisabeth Heimtun; Hadera, Mussie Ghezu; Eskeland, Ragnhild (Peer reviewed; Journal article, 2022)Epidemiological studies have linked long-term/high-dose usage of paracetamol (N-acetyl-para-aminophenol, APAP) during pregnancy to adverse neuropsychiatric outcomes, primarily attention-deficit hyperactive disorder (ADHD), ... -
The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells
Tingstad, Ragna Husby; Norheim, Frode Amador; Haugen, Fred; Feng, Yuan Zeng; Tunsjø, Hege; Thoresen, G. Hege; Rustan, Arild Christian; Charnock, Colin; Aas, Vigdis (Peer reviewed; Journal article, 2021)Skeletal muscle plays an important role in glycaemic control and metabolic homeostasis, making it a tissue of interest with respect to type 2 diabetes mellitus. The aim of the present study was to determine if ligands of ...