Browsing Brage by Author "Doherty, Jennifer A."

Now showing items 1-6 of 6

    • Genetic modifiers of radon-induced lung cancer risk. A genome-wide interaction study in former uranium miners 

      Rosenberger, Albert; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Haiman, C.A.; Albanes, Demetrios; Aldrich, Melinda; Tardon, Adonina; Fernandez-Tardon, G.; Rennert, Gad; Field, John K.; Kiemeney, B.; Lazarus, Philip; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Brunnsstöm, Hans; Goodman, Gary G.; Doherty, Jennifer A.; Chen, Chu; Teare, Dawn; Wichmann, H. Erich; Manz, Judith; Risch, Angela; Muley, Thomas R; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Amos, Christopher I.; Pesch, Beate; Johnen, Georg; Bruning, Thomas; Bickeboller, Heike; Gomolka, Maria (Peer reviewed; Journal article, 2018)
      Purpose: Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify ...

    • Gene–gene interaction of AhRwith and within the Wntcascade afects susceptibility to lung cancer 

      Rosenberger, Albert; Muttray, Nils; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Aldrich, Melinda C.; Tardon, Adonina; Fernández‑Tardón, Guillermo; Rennert, Gad; Field, John K.; Davies, Michael P. A.; Liloglou, Triantafllos; Kiemeney, Lambertus A.; Lazarus, Philip; Wendel, Bernadette; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Duell, Eric J.; Arnold, Susanne M.; Goodman, Gary G.; Chen, Chu; Doherty, Jennifer A.; Taylor, Fiona; Cox, Angela; Voll, Penella J.; Risch, Angela; Muley, Thomas R.; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Shete, Sanjay S.; Amos, Christopher I.; Bickeboller, Heike (Peer reviewed; Journal article, 2022)
      Background: Aberrant Wnt signalling, regulating cell development and stemness, infuences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex ...

    • Iam hiQ - a novel pair of accuracy indices for imputed genotypes 

      Rosenberger, Albert; Tozzi, Viola; Bickeböller, Heike; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Aldrich, Melinda C.; Tardon, Adonina; Fernandez-Tardon, Guillermo; Rennert, Gad; Field, John K.; Davies, Michael; Liloglou, Triantafillos; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Duell, Eric J.; Arnold, Susanne M.; Brunnström, Hans; Melander, Olle; Goodman, Gary E.; Chen, Chu; Doherty, Jennifer A.; Teare, M. Dawn; Cox, Angela; Woll, Penella J.; Risch, Angela; Muley, Thomas R.; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Shete, Sanjay S.; Amos, Christopher I. (Peer reviewed; Journal article, 2022)
      Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are ...

    • Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility 

      Kachuri, Linda; Johansson, Mattias; Rashkin, Sara R.; Graff, Rebecca E.; Bossé, Yohan; Manem, Venkata; Caporaso, Neil E.; Landi, Maria Teresa; Christiani, David C.; Vineis, Paolo; Liu, Geoffrey; Scelo, Ghislaine; Zaridze, David; Shete, Sanjay S.; Albanes, Demetrius; Aldrich, Melinda C.; Tardón, Adonina; Rennert, Gad; Chen, Chu; Goodman, Gary E.; Doherty, Jennifer A.; Bickeboller, Heike; Field, John K.; Davies, Michael P.; Teare, M. Dawn; Kiemeney, Lambertus A.; Bojesen, Stig E.; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Le Marchand, Loïc; Cheng, Iona; Schabath, Matthew B.; Duell, Eric J.; Andrew, Angeline S.; Manjer, Jonas; Lazarus, Philip; Arnold, Susanne; McKay, James D.; Emami, Nima C.; Warkentin, Matthew T.; Brhane, Yonathan; Obeidat, Ma’en; Martin, Richard M.; Relton, Caroline; Smith, George Davey; Haycock, Philip C.; Amos, Christopher I.; Brennan, Paul; Witte, John S.; Hung, Rayjean J. (Peer reviewed; Journal article, 2020)
      Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and ...

    • Mendelian randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers 

      Kachuri, Linda; Saarela, Olli; Bojesen, Stig E.; Smith, George Davey; Liu, Geoffrey; Landi, Maria Teresa; Caporaso, Neil E.; Christiani, David C.; Johansson, Mattias; Panico, Salvatore; Overvad, Kim; Trichopoulou, Antonia; Vineis, Paolo; Scelo, Ghislaine; Zaridze, David; Wu, Xifeng; Albanes, Demetrius; Diergaarde, Brenda; Lagiou, Pagona; Macfarlane, Gary J.; Aldrich, Melinda; Tardon, Adonina; Rennert, Gad; Olshan, Andrew F.; Weissler, Mark C.; Chen, Chu; Goodman, Gary E.; Doherty, Jennifer A.; Ness, Andrew R.; Bickeboller, Heike; Wichmann, H. Erich; Risch, Angela; Field, John K.; Teare, M. Dawn; Kiemeney, Lambertus; van der Heijden, Erik H. F. M.; Carroll, June C.; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Wunsch-Filho, Victor; Tajara, Eloiza H.; Moyses, Raquel Ajub; Nunes, Fabio Daumas; Lam, Stephen; Eluf-Neto, Jose; Lacko, Martin; Peters, Wilbert HM; Le Marchand, Loïc; Duell, Eric J.; Andrew, Angeline S.; Franceschi, Silvia; Schabath, Matthew B.; Manjer, Jonas; Arnold, Susanne; Lazarus, Philip; Mukeriya, Anush; Swiatkowska, Beata; Janout, Vladimir; Holcátová, Ivana; Stojsic, Jelena; Mates, Dana; Lissowska, Jolanta; Boccia, Stefania; Lesseur, Corina; Zong, Xuchen; McKay, James D.; Brennan, Paul; Amos, Christopher I.; Hung, Rayjean J. (Peer reviewed; Journal article, 2018)
      Background: Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck ...

    • Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study 

      Carreras-Torres, Robert; Haycock, Philip C.; Wade, Kaitlin H.; Relton, Caroline L.; Martin, Richard M.; Smith, George Davey; Albanes, Demetrius; Aldrich, Melinda C.; Andrew, Angeline S.; Arnold, Susanne M.; Bickeböller, Heike; Bojesen, Stig E.; Brunnström, Hans; Manjer, Jonas; Brüske, Irene; Caporaso, Neil E.; Chen, Chu; Christiani, David C.; Christian, W. Jay; Doherty, Jennifer A.; Duell, Eric J.; Field, John K.; Davies, Michael P. A.; Marcus, Michael W.; Goodman, Gary E.; Grankvist, Kjell; Haugen, Aage; Hong, Yun-Chul; Kiemeney, Lambertus A.; van der Heijden, Erik H. F. M.; Kraft, Peter; Johansson, Mikael B.; Lam, Stephen; Landi, Maria Teresa; Lazarus, Philip; Le Marchand, Loïc; Liu, Geoffrey; Melander, Olle; Park, Sungshim L.; Rennert, Gad; Risch, Angela; Haura, Eric B.; Scelo, Ghislaine; Zaridze, David; Mukeriya, Anush; Savić, Milan; Lissowska, Jolanta; Swiatkowska, Beata; Janout, Vladimir; Holcatova, Ivana; Mates, Dana; Schabath, Matthew B.; Shen, Hongbing; Tardon, Adonina; Teare, M Dawn; Woll, Penella; Tsao, Ming-Sound; Wu, Xifeng; Yuan, Jian-Min; Hung, Rayjean J.; Amos, Christopher I.; McKay, James; Brennan, Paul (Peer reviewed; Journal article, 2017)
      Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to ...