Browsing Brage by Author "Le Marchand, Loïc"

Now showing items 1-6 of 6

    • Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls 

      Wang, Yuzhuo; Gorlova, Olga Y.; Gorlov, Ivan P.; Zhu, Meng; Dai, Juncheng; Albanes, Demetrius; Lam, Stephen; Tardon, Adonina; Chen, Chu; Goodman, Gary E.; Bojesen, Stig E.; Landi, Maria Teresa; Johansson, Mattias; Risch, Angela; Wichmann, Heinz-Erich; Bickeboller, Heike; Christiani, David C.; Rennert, Gad; Arnold, Susanne M.; Brennan, Paul; Field, John K.; Shete, Sanjay; Le Marchand, Loïc; Melander, Olle; Brunnstrom, Hans; Liu, Geoffrey; Hung, Rayjean J.; Andrew, Angeline S.; Kiemeney, Lambertus A.; Zienolddiny, Shanbeh; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil E.; Woll, Penella J.; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Stevens, Victoria L.; Ma, Hongxia; Jin, Guangfu; Hu, Zhibin; Amos, Christopher I.; Shen, Hongbing (Peer reviewed; Journal article, 2020)
      Background: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been ...

    • Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers 

      Lesseur, Corina; Ferreiro-Iglesias, Aida; McKay, James D.; Bossé, Yohan; Johansson, Mattias; Gaborieau, Valerie; Landi, Maria Teresa; Christiani, David C.; Caporaso, Neil E.; Bojesen, Stig E.; Amos, Christopher I.; Shete, Sanjay S.; Liu, Geoffrey; Rennert, Gadi; Albanes, Demetrius; Aldrich, Melinda C.; Tardon, Adonina; Chen, Chu; Triantafillos, Liloglou; Field, John K.; Teare, Marion Dawn; Kiemeney, Lambertus A.; Diergaarde, Brenda; Ferris, Robert L.; Zienolddiny, Shanbeh; Lam, Stephen; Olshan, Andrew F.; Weissler, Mark C.; Lacko, Martin; Risch, Angela; Bickeböller, Heike; Ness, Andy R.; Thomas, Steve; Le Marchand, Loïc; Schabath, Matthew B.; Wunsch-Filho, Victor; Tajara, Eloiza H.; Andrew, Angeline S.; Clifford, Gary M.; Lazarus, Philip; Grankvist, Kjell; Johansson, Mikael; Arnold, Susanne; Melander, Olle; Brunnström, Hans; Boccia, Stefania; Cadoni, Gabriella; Timens, Wim; Obeidat, Ma’en; Xiao, Xiangjun; Houlston, Richard S.; Hung, Rayjean J.; Brennan, Paul (Peer reviewed; Journal article, 2021)
      Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic ...

    • Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility 

      Kachuri, Linda; Johansson, Mattias; Rashkin, Sara R.; Graff, Rebecca E.; Bossé, Yohan; Manem, Venkata; Caporaso, Neil E.; Landi, Maria Teresa; Christiani, David C.; Vineis, Paolo; Liu, Geoffrey; Scelo, Ghislaine; Zaridze, David; Shete, Sanjay S.; Albanes, Demetrius; Aldrich, Melinda C.; Tardón, Adonina; Rennert, Gad; Chen, Chu; Goodman, Gary E.; Doherty, Jennifer A.; Bickeboller, Heike; Field, John K.; Davies, Michael P.; Teare, M. Dawn; Kiemeney, Lambertus A.; Bojesen, Stig E.; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Le Marchand, Loïc; Cheng, Iona; Schabath, Matthew B.; Duell, Eric J.; Andrew, Angeline S.; Manjer, Jonas; Lazarus, Philip; Arnold, Susanne; McKay, James D.; Emami, Nima C.; Warkentin, Matthew T.; Brhane, Yonathan; Obeidat, Ma’en; Martin, Richard M.; Relton, Caroline; Smith, George Davey; Haycock, Philip C.; Amos, Christopher I.; Brennan, Paul; Witte, John S.; Hung, Rayjean J. (Peer reviewed; Journal article, 2020)
      Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and ...

    • Mendelian randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers 

      Kachuri, Linda; Saarela, Olli; Bojesen, Stig E.; Smith, George Davey; Liu, Geoffrey; Landi, Maria Teresa; Caporaso, Neil E.; Christiani, David C.; Johansson, Mattias; Panico, Salvatore; Overvad, Kim; Trichopoulou, Antonia; Vineis, Paolo; Scelo, Ghislaine; Zaridze, David; Wu, Xifeng; Albanes, Demetrius; Diergaarde, Brenda; Lagiou, Pagona; Macfarlane, Gary J.; Aldrich, Melinda; Tardon, Adonina; Rennert, Gad; Olshan, Andrew F.; Weissler, Mark C.; Chen, Chu; Goodman, Gary E.; Doherty, Jennifer A.; Ness, Andrew R.; Bickeboller, Heike; Wichmann, H. Erich; Risch, Angela; Field, John K.; Teare, M. Dawn; Kiemeney, Lambertus; van der Heijden, Erik H. F. M.; Carroll, June C.; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Wunsch-Filho, Victor; Tajara, Eloiza H.; Moyses, Raquel Ajub; Nunes, Fabio Daumas; Lam, Stephen; Eluf-Neto, Jose; Lacko, Martin; Peters, Wilbert HM; Le Marchand, Loïc; Duell, Eric J.; Andrew, Angeline S.; Franceschi, Silvia; Schabath, Matthew B.; Manjer, Jonas; Arnold, Susanne; Lazarus, Philip; Mukeriya, Anush; Swiatkowska, Beata; Janout, Vladimir; Holcátová, Ivana; Stojsic, Jelena; Mates, Dana; Lissowska, Jolanta; Boccia, Stefania; Lesseur, Corina; Zong, Xuchen; McKay, James D.; Brennan, Paul; Amos, Christopher I.; Hung, Rayjean J. (Peer reviewed; Journal article, 2018)
      Background: Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck ...

    • Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study 

      Carreras-Torres, Robert; Haycock, Philip C.; Wade, Kaitlin H.; Relton, Caroline L.; Martin, Richard M.; Smith, George Davey; Albanes, Demetrius; Aldrich, Melinda C.; Andrew, Angeline S.; Arnold, Susanne M.; Bickeböller, Heike; Bojesen, Stig E.; Brunnström, Hans; Manjer, Jonas; Brüske, Irene; Caporaso, Neil E.; Chen, Chu; Christiani, David C.; Christian, W. Jay; Doherty, Jennifer A.; Duell, Eric J.; Field, John K.; Davies, Michael P. A.; Marcus, Michael W.; Goodman, Gary E.; Grankvist, Kjell; Haugen, Aage; Hong, Yun-Chul; Kiemeney, Lambertus A.; van der Heijden, Erik H. F. M.; Kraft, Peter; Johansson, Mikael B.; Lam, Stephen; Landi, Maria Teresa; Lazarus, Philip; Le Marchand, Loïc; Liu, Geoffrey; Melander, Olle; Park, Sungshim L.; Rennert, Gad; Risch, Angela; Haura, Eric B.; Scelo, Ghislaine; Zaridze, David; Mukeriya, Anush; Savić, Milan; Lissowska, Jolanta; Swiatkowska, Beata; Janout, Vladimir; Holcatova, Ivana; Mates, Dana; Schabath, Matthew B.; Shen, Hongbing; Tardon, Adonina; Teare, M Dawn; Woll, Penella; Tsao, Ming-Sound; Wu, Xifeng; Yuan, Jian-Min; Hung, Rayjean J.; Amos, Christopher I.; McKay, James; Brennan, Paul (Peer reviewed; Journal article, 2017)
      Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to ...

    • Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci 

      Dai, Juncheng; Li, Zhihua; Amos, Christopher I.; Hung, Rayjean J.; Tardon, Adonina; Andrew, Angeline; Chen, Chu; Christiani, David C.; Albanes, Demetrios; van der Heijden, Erik H. F. M.; Duell, Eric J.; Rennert, Gadi; McKay, James D.; Yuan, Jian-Min; Field, John K.; Manjer, Jonas; Grankvist, Kjell; Le Marchand, Loïc; Teare, Dawn; Schabath, Matthew B.; Aldrich, Melinda C.; Tsao, Ming-Sound; Lazarus, Philip; Lam, Stephen; Bojesen, Stig E.; Arnold, Susanne; Wu, Xifeng; Haugen, Aage; Janout, Vladimir; Johansson, Mikael; Brhane, Yonathan; Fernandez-Somoano, Ana; Kiemeney, Lambertus A.; Davies, Michael; Zienolddiny, Shanbeh; Hu, Zhibin; Shen, Hongbing (Peer reviewed; Journal article, 2019)
      DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in ...