Blar i Brage på forfatter "Caporaso, Neil E."
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Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model
Hung, Rayjean J.; Warkentin, Matthew T.; Brhane, Yonathan; Chatterjee, Nilanjan; Christiani, David C.; Landi, Maria Teresa; Caporaso, Neil E.; Liu, Geoffrey; Johansson, Mattias; Albanes, Demetrius; Le Marchand, Loic; Tardon, Adonina; Rennert, Gad; Bojesen, Stig E.; Chen, Chu; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Zienolddiny, Shanbeh; Lam, Stephen; Andrew, Angeline S.; Arnold, Susanne M.; Aldrich, Melinda C.; Bickeböller, Heike; Risch, Angela; Schabath, Matthew B.; McKay, James D.; Brennan, Paul; Amos, Christopher I. (Peer reviewed; Journal article, 2021)Lung cancer is the leading cause of cancer-related death globally. An improved risk stratification strategy can increase efficiency of low-dose CT (LDCT) screening. Here we assessed whether individual's genetic background ... -
Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls
Wang, Yuzhuo; Gorlova, Olga Y.; Gorlov, Ivan P.; Zhu, Meng; Dai, Juncheng; Albanes, Demetrius; Lam, Stephen; Tardon, Adonina; Chen, Chu; Goodman, Gary E.; Bojesen, Stig E.; Landi, Maria Teresa; Johansson, Mattias; Risch, Angela; Wichmann, Heinz-Erich; Bickeboller, Heike; Christiani, David C.; Rennert, Gad; Arnold, Susanne M.; Brennan, Paul; Field, John K.; Shete, Sanjay; Le Marchand, Loïc; Melander, Olle; Brunnstrom, Hans; Liu, Geoffrey; Hung, Rayjean J.; Andrew, Angeline S.; Kiemeney, Lambertus A.; Zienolddiny, Shanbeh; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil E.; Woll, Penella J.; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Stevens, Victoria L.; Ma, Hongxia; Jin, Guangfu; Hu, Zhibin; Amos, Christopher I.; Shen, Hongbing (Peer reviewed; Journal article, 2020)Background: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been ... -
Elevated platelet count appears to be causally associated with increased risk of lung cancer. A Mendelian randomization analysis
Zhu, Ying; Wei, Yongyue; Zhang, Ruyang; Dong, Xuesi; Shen, Sipeng; Zhao, Yang; Bai, Jianling; Albanes, Demetrius; Caporaso, Neil E.; Landi, Maria Teresa; Zhu, Bin; Chanock, Stephen J.; Gu, Fangyi; Lam, Stephen; Ming-Sound, Tsao; Shepherd, Frances A.; Tardon, Adonina; Fernández-Somoano, Ana; Fernandez-Tardon, Guillermo; Chen, Chu; Barnett, Matthew J.; Doherty, Jennifer; Bojesen, Stig E.; Johansson, Mattias; Brennan, Paul; McKay, James D.; Carreras-Torres, Robert; Muley, Thomas; Risch, Angela; Wichmann, Heinz-Erich; Bickeboller, Heike; Rosenberger, Albert; Rennert, Gad; Saliba, Walid; Arnold, Susanne; Field, John K.; Davies, Michael P.A.; Marcus, Michael W.; Wu, Xifeng; Ye, Yuanqing; Le Marchand, Loic; Wilkens, Lynne R.; Melander, Olle; Manjer, Jonas; Brunnström, Hans; Hung, Rayjean J.; Liu, Geoffrey; Brhane, Yonathan; Kachuri, Linda; Andrew, Angeline S.; Duell, Eric J.; Kiemeney, Lambertus A.; van der Heijden, Erik H. F. M.; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Grankvist, Kjell; Johansson, Mikael; Woll, Penella; Cox, Angela; Taylor, Fiona; Teare, Dawn; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Houlston, Richard S.; McLaughlin, John; Stevens, Victoria L.; Shen, Hongbing; Hu, Zhibin; Dai, Juncheng; Amos, Christopher I.; Han, Younghun; Zhu, Dakai; Goodman, Gary E.; Chen, Feng; Christiani, David C. (Peer reviewed; Journal article, 2019)Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung ... -
Gene–gene interaction of AhRwith and within the Wntcascade afects susceptibility to lung cancer
Rosenberger, Albert; Muttray, Nils; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Aldrich, Melinda C.; Tardon, Adonina; Fernández‑Tardón, Guillermo; Rennert, Gad; Field, John K.; Davies, Michael P. A.; Liloglou, Triantafllos; Kiemeney, Lambertus A.; Lazarus, Philip; Wendel, Bernadette; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Duell, Eric J.; Arnold, Susanne M.; Goodman, Gary G.; Chen, Chu; Doherty, Jennifer A.; Taylor, Fiona; Cox, Angela; Voll, Penella J.; Risch, Angela; Muley, Thomas R.; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Shete, Sanjay S.; Amos, Christopher I.; Bickeboller, Heike (Peer reviewed; Journal article, 2022)Background: Aberrant Wnt signalling, regulating cell development and stemness, infuences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex ... -
Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers
Lesseur, Corina; Ferreiro-Iglesias, Aida; McKay, James D.; Bossé, Yohan; Johansson, Mattias; Gaborieau, Valerie; Landi, Maria Teresa; Christiani, David C.; Caporaso, Neil E.; Bojesen, Stig E.; Amos, Christopher I.; Shete, Sanjay S.; Liu, Geoffrey; Rennert, Gadi; Albanes, Demetrius; Aldrich, Melinda C.; Tardon, Adonina; Chen, Chu; Triantafillos, Liloglou; Field, John K.; Teare, Marion Dawn; Kiemeney, Lambertus A.; Diergaarde, Brenda; Ferris, Robert L.; Zienolddiny, Shanbeh; Lam, Stephen; Olshan, Andrew F.; Weissler, Mark C.; Lacko, Martin; Risch, Angela; Bickeböller, Heike; Ness, Andy R.; Thomas, Steve; Le Marchand, Loïc; Schabath, Matthew B.; Wunsch-Filho, Victor; Tajara, Eloiza H.; Andrew, Angeline S.; Clifford, Gary M.; Lazarus, Philip; Grankvist, Kjell; Johansson, Mikael; Arnold, Susanne; Melander, Olle; Brunnström, Hans; Boccia, Stefania; Cadoni, Gabriella; Timens, Wim; Obeidat, Ma’en; Xiao, Xiangjun; Houlston, Richard S.; Hung, Rayjean J.; Brennan, Paul (Peer reviewed; Journal article, 2021)Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic ... -
Iam hiQ - a novel pair of accuracy indices for imputed genotypes
Rosenberger, Albert; Tozzi, Viola; Bickeböller, Heike; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Aldrich, Melinda C.; Tardon, Adonina; Fernandez-Tardon, Guillermo; Rennert, Gad; Field, John K.; Davies, Michael; Liloglou, Triantafillos; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Duell, Eric J.; Arnold, Susanne M.; Brunnström, Hans; Melander, Olle; Goodman, Gary E.; Chen, Chu; Doherty, Jennifer A.; Teare, M. Dawn; Cox, Angela; Woll, Penella J.; Risch, Angela; Muley, Thomas R.; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Shete, Sanjay S.; Amos, Christopher I. (Peer reviewed; Journal article, 2022)Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are ... -
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
Kachuri, Linda; Johansson, Mattias; Rashkin, Sara R.; Graff, Rebecca E.; Bossé, Yohan; Manem, Venkata; Caporaso, Neil E.; Landi, Maria Teresa; Christiani, David C.; Vineis, Paolo; Liu, Geoffrey; Scelo, Ghislaine; Zaridze, David; Shete, Sanjay S.; Albanes, Demetrius; Aldrich, Melinda C.; Tardón, Adonina; Rennert, Gad; Chen, Chu; Goodman, Gary E.; Doherty, Jennifer A.; Bickeboller, Heike; Field, John K.; Davies, Michael P.; Teare, M. Dawn; Kiemeney, Lambertus A.; Bojesen, Stig E.; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Le Marchand, Loïc; Cheng, Iona; Schabath, Matthew B.; Duell, Eric J.; Andrew, Angeline S.; Manjer, Jonas; Lazarus, Philip; Arnold, Susanne; McKay, James D.; Emami, Nima C.; Warkentin, Matthew T.; Brhane, Yonathan; Obeidat, Ma’en; Martin, Richard M.; Relton, Caroline; Smith, George Davey; Haycock, Philip C.; Amos, Christopher I.; Brennan, Paul; Witte, John S.; Hung, Rayjean J. (Peer reviewed; Journal article, 2020)Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and ...