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    • Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma 

      Qin, Na; Li, Yuancheng; Wang, Cheng; Zhu, Meng; Dai, Juncheng; Hong, Tongtong; Albanes, Demetrius; Lam, Stephen; Tardón, Adonina; Chen, Chu; Goodman, Gary; Bojesen, Stig E.; Landi, Maria Teresa; Johansson, Mattias; Risch, Angela; Wichmann, H-Erich; Bickeboller, Heike; Rennert, Gadi; Arnold, Susanne; Brennan, Paul; Field, John K.; Shete, Sanjay; Le Marchand, Loic; Melander, Olle; Brunnstrom, Hans; Liu, Geoffrey; Hung, Rayjean J.; Andrew, Angeline; Kiemeney, Lambertus A.; Zienolddiny, Shanbeh; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil; Woll, Penella; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Stevens, Victoria L.; Jin, Guangfu; Christiani, David C.; Hu, Zhibin; Amos, Christopher I.; Ma, Hongxia; Shen, Hongbing (Peer reviewed; Journal article, 2020)
      Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating ...

    • Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers 

      Lesseur, Corina; Ferreiro-Iglesias, Aida; McKay, James D.; Bossé, Yohan; Johansson, Mattias; Gaborieau, Valerie; Landi, Maria Teresa; Christiani, David C.; Caporaso, Neil E.; Bojesen, Stig E.; Amos, Christopher I.; Shete, Sanjay S.; Liu, Geoffrey; Rennert, Gadi; Albanes, Demetrius; Aldrich, Melinda C.; Tardon, Adonina; Chen, Chu; Triantafillos, Liloglou; Field, John K.; Teare, Marion Dawn; Kiemeney, Lambertus A.; Diergaarde, Brenda; Ferris, Robert L.; Zienolddiny, Shanbeh; Lam, Stephen; Olshan, Andrew F.; Weissler, Mark C.; Lacko, Martin; Risch, Angela; Bickeböller, Heike; Ness, Andy R.; Thomas, Steve; Le Marchand, Loïc; Schabath, Matthew B.; Wunsch-Filho, Victor; Tajara, Eloiza H.; Andrew, Angeline S.; Clifford, Gary M.; Lazarus, Philip; Grankvist, Kjell; Johansson, Mikael; Arnold, Susanne; Melander, Olle; Brunnström, Hans; Boccia, Stefania; Cadoni, Gabriella; Timens, Wim; Obeidat, Ma’en; Xiao, Xiangjun; Houlston, Richard S.; Hung, Rayjean J.; Brennan, Paul (Peer reviewed; Journal article, 2021)
      Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic ...

    • Lung cancer risk in never smokers of European descent is associated with genetic variation in the 5P15.33 TERT-CLPTM1L Region 

      Hung, Rayjean J.; Spitz, Margaret R.; Houlston, Richard S.; Schwartz, Ann G.; Field, John K.; Ying, Jun; Li, Yafang; Han, Younghun; Ji, Xuemei; Chen, Wei; Wu, Xifeng; Gorlov, Ivan P.; Na, Jie; Andrade, Mariza de; Liu, Geoffrey; Brhane, Yonathan; Diao, Nancy; Wenzlaff, Angela; Davies, Michael P.A.; Liloglou, Triantafillos; Timofeeva, Maria; Muley, Thomas; Rennert, Hedy; Saliba, Walid; Ryan, Bríd M.; Bowman, Elise; Barros-Dios, Juan-Miguel; Pérez-Ríos, Mónica; Morgenstern, Hal; Zienolddiny, Shanbeh; Skaug, Vidar; Ugolini, Donatella; Bonassi, Stefano; van der Heijden, Erik H.F.M.; Tardon, Adonina; Bojesen, Stig; Landi, Maria Teresa; Johansson, Mattias; Bickeböller, Heike; Arnold, Susanne; Le Marchand, Loic; Melander, Olle; Andrew, Angeline; Grankvist, Kjell; Caporaso, Neil; Teare, M. Dawn; Schabath, Matthew B.; Aldrich, Melinda C.; Kiemeney, Lambertus A.; H-Erich, Wichmann; Lazarus, Philip; Mayordomo, Jose; Neri, Monica; Haugen, Aage; Zhang, Zuo-Feng; Ruano-Raviña, Alberto; Brenner, Hermann; Harris, Curtis C.; Orlow, Irene; Rennert, Gadi; Risch, Angela; Brennan, Paul; Christiani, David C.; Amos, Christopher I.; Yang, Ping; Gorlova, Olga Y. (Peer reviewed; Journal article, 2019)
      Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult ...

    • Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci 

      Dai, Juncheng; Li, Zhihua; Amos, Christopher I.; Hung, Rayjean J.; Tardon, Adonina; Andrew, Angeline; Chen, Chu; Christiani, David C.; Albanes, Demetrios; van der Heijden, Erik H. F. M.; Duell, Eric J.; Rennert, Gadi; McKay, James D.; Yuan, Jian-Min; Field, John K.; Manjer, Jonas; Grankvist, Kjell; Le Marchand, Loïc; Teare, Dawn; Schabath, Matthew B.; Aldrich, Melinda C.; Tsao, Ming-Sound; Lazarus, Philip; Lam, Stephen; Bojesen, Stig E.; Arnold, Susanne; Wu, Xifeng; Haugen, Aage; Janout, Vladimir; Johansson, Mikael; Brhane, Yonathan; Fernandez-Somoano, Ana; Kiemeney, Lambertus A.; Davies, Michael; Zienolddiny, Shanbeh; Hu, Zhibin; Shen, Hongbing (Peer reviewed; Journal article, 2019)
      DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in ...