Browsing Brage by Author "Wallin, Håkan"
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Accelerated atherosclerosis caused by serum amyloid A response in lungs of ApoE−/− mice
Christophersen, Daniel Vest; Møller, Peter; Thomsen, Morten Bækgaard; Lykkesfeldt, Jens; Loft, Steffen; Wallin, Håkan; Vogel, Ulla; Jacobsen, Nicklas Raun (Peer reviewed; Journal article, 2021)Airway exposure to eg particulate matter is associated with cardiovascular disease including atherosclerosis. Acute phase genes, especially Serum Amyloid A3 (Saa3), are highly expressed in the lung following pulmonary ... -
Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice
Hadrup, Niels; Rahmani, Feriel; Jacobsen, Nicklas R.; Saber, Anne T.; Jackson, Petra; Bengtson, Stefan; Williams, Andrew; Wallin, Håkan; Halappanavar, Sabina; Vogel, Ulla (Peer reviewed; Journal article, 2019)Inhalation of nanosized zinc oxide (ZnO) induces metal fume fever and systemic acute phase response in humans. Acute phase response activation is a cardiovascular risk factor; we investigated whether pulmonary exposure of ... -
In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT
Di Ianni, Emilio; Samulin-Erdem, Johanna Maria; Møller, Peter; Sahlgren, Nicklas Mønster; Poulsen, Sarah Søs; Knudsen, Kristina Bram; Zienolddiny, Shanbeh; Saber, Anne Thoustrup; Wallin, Håkan; Vogel, Ulla; Jacobsen, Nicklas Raun (Peer reviewed; Journal article, 2021)Background Multi-walled carbon nanotubes (MWCNT) have received attention due to extraordinary properties, resulting in concerns for occupational health and safety. Costs and ethical concerns of animal testing drive a need ... -
Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: Investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles
Hadrup, Niels; Bengtson, Stefan; Jacobsen, Nicklas R. ; Jackson, Petra; Nocun, Marek ; Saber, Anne T.; Jensen, Keld A. ; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2017)Intratracheal instillation serves as a model for inhalation exposure. However, for this, materials are dispersed in appropriate media that may influence toxicity. We tested whether different intratracheal instillation ... -
Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation
Mech, A.; Rasmussen, K.; Jantunen, P.; Aicher, L.; Alessandrelli, M.; Bernauer, U.; Bleeker, E. A. J.; Bouillard, J.; Di Prospero Fanghella, P.; Draisci, R.; Dusinska, Maria; Encheva, G.; Flament, G.; Haase, A.; Handzhiyski, Y.; Herzberg, F.; Huwyler, J.; Jacobsen, N.R.; Jeliazkov, V.; Jeliazkova, N.; Nymark, P.; Grafström, R.; Oomen, A. G.; Polci, M. L.; Riebeling, C.; Sandström, J.; Shivachev, B.; Stateva, S.; Tanasescu, S.; Tsekovska, R.; Wallin, Håkan; Wilks, M. F.; Zellmer, S.; Apostolova, M. D. (Peer reviewed; Journal article, 2018)This paper presents a comprehensive review of European Union (EU) legislation addressing the safety of chemical substances, and possibilities within each piece of legislation for applying grouping and read-across approaches ... -
Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity
Poulsen, Sarah S.; Jackson, Petra; Kling, Kirsten; Knudsen, Kristina B.; Skaug, Vidar; Kyjovska, Zdenka O.; Thomsen, Birthe L.; Clausen, Per A.; Atluri, Rambabu; Berthing, Trine; Bengtson, Stefan; Wolff, Henrik; Jensen, Keld A.; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2016)Lung deposition of multi-walled carbon nanotubes (MWCNT) induces pulmonary toxicity. Commercial MWCNT vary greatly in physicochemical properties and consequently in biological effects. To identify determinants of MWCNT-induced ... -
Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis
Rahman, Luna; Jacobsen, Nicklas Raun; Aziz, Syed Abdul; Wu, Dongmei; Williams, Andrew; Yauk, Carole L.; White, Paul; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina (Peer reviewed; Journal article, 2017)The International Agency for Research on Cancer has classified one type of multi-walled carbon nanotubes (MWCNTs) as possibly carcinogenic to humans. However, the underlying mechanisms of MWCNT- induced carcinogenicity are ... -
Nanomaterial grouping: Existing approaches and future recommendations
Giusti, Anna; Atluri, Rambabu; Tsekovska, Rositsa; Gajewicz, Agnieszka; Apostolova, Margarita; Battistelli, Chiara L.; Bleeker, Eric; Bossa, Cecilia; Bouillard, Jaques; Dusinska, Maria; Gómez-Fernández, Paloma; Grafström, Roland; Gromelski, Maciej; Handzhiyski, Yordan; Jacobsen, Nicklas Raun; Jantunen, Paula; Jensen, Keld Alstrup; Mech, Agnieszka; Navas, José Maria; Nymark, Penny; Oomen, Agnes G.; Puzyn, Tomasz; Rasmussen, Kirsten; Riebeling, Christian; Rodriguez-LLopis, Isabel; Sabella, Stefania; Sintes, Juan Riego; Suarez-Merino, Blanca; Tanasescu, Speranta; Wallin, Håkan; Haase, Andrea (Peer reviewed; Journal article, 2019)The physico-chemical properties of manufactured nanomaterials (NMs) can be fine-tuned to obtain different functionalities addressing the needs of specific industrial applications. The physico-chemical properties of NMs ... -
Physicochemical predictors of Multi‐Walled Carbon Nanotube‐induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different Multi‐Walled Carbon Nanotubes in mice
Knudsen, Kristina Bram; Berthing, Trine; Jackson, Petra; Poulsen, Sarah S.; Mortensen, Alicja; Jacobsen, Nicklas Raun; Skaug, Vidar; Szarek, Józef; Hougaard, Karin Sørig; Wollf, Henrik; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2018)Multi‐walled carbon nanotubes (MWCNT) are widely used nanomaterials that cause pulmonary toxicity upon inhalation. The physicochemical properties of MWCNT vary greatly, which makes general safety evaluation challenging to ... -
Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure
Danielsen, Pernille Høgh; Poulsen, Sarah Søs; Knudsen, Kristina Bram; Clausen, Per Axel; Jensen, Keld Alstrup; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2024)Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 ... -
Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
Hadrup, Niels; Knudsen, Kristina Bram; Berthing, Trine; Wolff, Henrik; Bengtson, Stefan; Kofoed, Christian; Espersen, Roall; Højgaard, Casper; Winther, Jakob Rahr; Willemoës, Martin; Wedin, Irene; Nuopponen, Markus; Alenius, Harri; Norppa, Hannu; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2019)We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE ... -
Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials. Inflammation and DNA strand breaks
Hadrup, Niels; Saber, Anne T.; Kyjovska, Zdenka O.; Jacobsen, Nicklas R.; Vippola, Minnamari; Sarlin, Essi; Ding, Yaobo; Schmid, Otmar; Wallin, Håkan; Jensen, Keld A. ; Vogel, Ulla (Peer reviewed; Journal article, 2019)Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 ... -
Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure
Gaté, Laurent; Knudsen, Kristina Bram; Seidel, Carole; Berthing, Trine; Chézeau, Laëtitia; Jacobsen, Nicklas Raun; Valentino, Sarah; Wallin, Håkan; Bau, Sébastien; Wolff, Henrik; Sébillaud, Sylvie; Lorcin, Mylène; Grossmann, Stéphane; Viton, Stéphane; Nunge, Hervé; Darne, Christian; Vogel, Ulla; Cosnier, Frédéric (Peer reviewed; Journal article, 2019)Multi-walled carbon nanotubes (MWCNTs), which vary in length, diameter, functionalization and specific surface area, are used in diverse industrial processes. Since these nanomaterials have a high aspect ratio and are ... -
Ranking of nanomaterial potency to induce pathway perturbations associated with lung responses
Halappanavar, Sabina; Rahman, Luna; Nikota, Jake; Poulsen, Sarah S.; Ding, Yaobo; Jackson, Petra; Wallin, Håkan; Schmid, Otmar; Vogel, Ulla; Williams, Andrew (Peer reviewed; Journal article, 2019)Global transcriptomic responses in lungs of mice exposed for 24 h to individual multi-walled carbon nanotubes (MWCNTs, ten different types), nano titanium dioxide (nano TiO2, nine different types) and one type of carbon ... -
Safe-by-design strategies for lowering the genotoxicity and pulmonary inflammation of multiwalled carbon nanotubes: Reduction of length and the introduction of COOH groups
Hadrup, Niels; Knudsen, Kristina Bram; Carriere, Marie; Mayne-L'Hermite, Martine; Bobyk, Laure; Allard, Soline; Miserque, Frédéric; Pibaleau, Baptiste; Pinault, Mathieu; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2021)Potentially, the toxicity of multiwalled carbon nanotubes (MWCNTs) can be reduced in a safe-by-design strategy. We investigated if genotoxicity and pulmonary inflammation of MWCNTs from the same batch were lowered by a) ... -
Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs
Solorio-Rodriguez, Silvia Aidee; Williams, Andrew; Poulsen, Sarah Søs; Knudsen, Kristina Bram; Jensen, Keld Alstrup; Clausen, Per Axel; Danielsen, Pernille Høgh; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina (Peer reviewed; Journal article, 2023)Single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) are nanomaterials with one or multiple layers of carbon sheets. While it is suggested that various properties influence their toxicity, the ... -
Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework
Nikota, Jake; Banville, Allyson; Goodwin, Laura Rose; Wu, Dongmei; Williams, Andrew; Yauk, Carole Lynn; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina (Peer reviewed; Journal article, 2017) -
Toxicity of pristine and paint-embedded TiO2 nanomaterials
Saber, A.T.; Mortensen, A.; Szarek, J.; Jacobsen, N.R.; Levin, M.; Koponen, I.K.; Jensen, K.A.; Vogel, U.; Wallin, Håkan (Peer reviewed; Journal article, 2019)Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing ... -
Unchanged pulmonary toxicity of ZnO nanoparticles formulated in a liquid matrix for glass coating
Saber, Anne Thoustrup; Hadrup, Niels; Williams, Andrew; Mortensen, Alicja; Szarek, Józef; Kyjovska, Zdenka; Kurz, Alexander; Jacobsen, Nicklas Raun; Wallin, Håkan; Halappanavar, Sabina; Vogel, Ulla (Peer reviewed; Journal article, 2022)The inclusion of nanoparticles can increase the quality of certain products. One application is the inclusion of Zinc oxide (ZnO) nanoparticles in a glass coating matrix to produce a UV-absorbing coating for glass sheets. ...