Blar i Brage på forfatter "Zimmer, Karin Elisabeth"
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A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro
Yadav, Ajay; Verhaegen, Steven; Verbruggen, Evelien; Kerhoas, Marie; Huiberts, Eva Henriëtte Willemijn; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Paulsen, Ragnhild Elisabeth (Peer reviewed; Journal article, 2021)Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were used to explore the effects on developmental neurotoxicity by a complex defined mixture of persistent organic pollutants (POPs). Its ... -
A mixture of Persistent Organic Pollutants (POPs) and Azoxymethane (AOM) show potential synergistic effects on intestinal tumorigenesis in the A/J Min/+ mouse model
Hansen, Kristine Eraker Aasland; Johanson, Silje Modahl; Steppeler, Christina; Sødring, Marianne Sundt; Østby, Gunn Charlotte; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Aleksandersen, Mona; Paulsen, Jan Erik; Ropstad, Erik (Peer reviewed; Journal article, 2018) -
Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests. A small scale study
Hansen, Kristine Eraker Aasland; Hudecova, Alexandra Misci; Haugen, Fred; Skjerve, Eystein; Ropstad, Erik; Zimmer, Karin Elisabeth (Peer reviewed; Journal article, 2022)BACKGROUND All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J, ... -
Effects of Defined Mixtures of Persistent Organic Pollutants (POPs) on Pre-lethal Cytotoxicity in the Human A-498 Kidney Cell Line In Vitro
Amber, Mazia; Xie, Yuling; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, Lisa (Peer reviewed; Journal article, 2021)A total mixture of 29 persistent organic pollutants (POPs) modelled from Scandinavian blood concentrations was used to expose human A-498 kidney cells for 24 h over a concentration range spanning below to above blood level ... -
Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo
Yadav, Ajay; Verhaegen, Steven; Filis, Panagiotis; Domanska, Diana; Lyle, Robert; Sundaram, Arvind; Leithaug, Magnus; Østby, Gunn Charlotte; Aleksandersen, Mona; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Fowler, Paul A.; Paulsen, Ragnhild Elisabeth Heimtun; Ropstad, Erik (Peer reviewed; Journal article, 2022)Prenatal exposure to persistent organic pollutants (POPs) is associated with neurodevelopmental disorders. In the present study, we explored whether a human-relevant POP mixture affects the development of chicken embryo ... -
Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice
Sinioja, Tim; Bodin, Johanna Eva; Duberg, Daniel; Dirven, Hubert; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Nygaard, Unni Cecilie; Orešič, Matej; Hyötyläinen, Tuulia (Peer reviewed; Journal article, 2022)Introduction Autoimmune disorders such as type 1 diabetes (T1D) are believed to be caused by the interplay between several genetic and environmental factors. Elucidation of the role of environmental factors in metabolic ... -
Human blood-based exposure levels of persistent organic pollutant (POP)mixtures antagonise androgen receptor transactivation and translocation
McComb, J.; Mills, I.G.; Muller, M.; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, S. (Peer reviewed; Journal article, 2019)Introduction Human exposure to persistent organic pollutants (POPs) has been linked to genitourinary health-related conditions such as decreased sperm quality, hypospadias, and prostate cancer (PCa). Conventional risk ... -
Lipogenic Potency of Individual Perfuorinated Alkyl Acids (PFAAs) and Persistent Organic Pollutant (POP) Mixtures at Human Blood‑Based Exposure Levels on Adipogenesis in 3T3‑L1 Cells
Xie, Y.; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, L. (Peer reviewed; Journal article, 2021)In recent decades, the incidence of metabolic disorders has increased internationally. This increase has been linked to exposure to persistent organic pollutants (POPs), but little is known about the metabolic efects of ... -
Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus
Myhre, Oddvar; Zimmer, Karin Elisabeth; Hudecova, Alexandra Misci; Hansen, Kristine Eraker Aasland; Khezri, Abdolrahman; Berntsen, Hanne Friis; Berg, Vidar; Lyche, Jan Ludvig; Mandal, Siddhartha; Duale, Nur; Ropstad, Erik (Peer reviewed; Journal article, 2021)Male and female mice pups were exposed to a low and high dose of a human relevant mixture of persistent organic pollutants (POPs) during pregnancy and lactation. Most compounds detected in the dams were found in offspring ... -
Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice
Johanson, Silje Modahl; Swann, Jonathan R.; Umu, Özgün Candan Onarman; Aleksandersen, Mona; Müller, Mette Helen Bjørge; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Østby, Gunn Charlotte; Paulsen, Jan Erik; Ropstad, Erik (Peer reviewed; Journal article, 2020)An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the ... -
Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice
Johanson, Silje Modahl; Ropstad, Erik; Østby, Gunn Charlotte; Aleksandersen, Mona; Zamaratskaia, Galia; Boge, Gudrun Seeberg; Halsne, Ruth; Trangerud, Cathrine; Lyche, Jan Ludvig; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Verhaegen, Steven (Peer reviewed; Journal article, 2021)The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the ... -
Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure
Yadav, Ajay; Verhaegen, Steven; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Berg, Vidar; Lyche, Jan Ludvig; Sabaredzovic, Azemira; Haug, Line Småstuen; Myhre, Oddvar; Zimmer, Karin Elisabeth; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Boix, Fernando (Peer reviewed; Journal article, 2021) -
Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes
McGlinchey, Aidan; Sinioja, Tim; Lamichhane, Santosh; Sen, Partho; Bodin, Johanna Eva; Siljander, Heli; Dickens, Alex M.; Geng, Dawei; Carlsson, Cecilia; Duberg, Daniel; Ilonen, Jorma; Virtanen, Suvi M.; Dirven, Hubert; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Nygaard, Unni Cecilie; Orešič, Matej; Knip, Mikael; Hyötyläinen, Tuulia (Peer reviewed; Journal article, 2020)In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their ...