Browsing Brage by Author "Hadrup, Niels"
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Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice
Hadrup, Niels; Rahmani, Feriel; Jacobsen, Nicklas R.; Saber, Anne T.; Jackson, Petra; Bengtson, Stefan; Williams, Andrew; Wallin, Håkan; Halappanavar, Sabina; Vogel, Ulla (Peer reviewed; Journal article, 2019)Inhalation of nanosized zinc oxide (ZnO) induces metal fume fever and systemic acute phase response in humans. Acute phase response activation is a cardiovascular risk factor; we investigated whether pulmonary exposure of ... -
Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: Investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles
Hadrup, Niels; Bengtson, Stefan; Jacobsen, Nicklas R. ; Jackson, Petra; Nocun, Marek ; Saber, Anne T.; Jensen, Keld A. ; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2017)Intratracheal instillation serves as a model for inhalation exposure. However, for this, materials are dispersed in appropriate media that may influence toxicity. We tested whether different intratracheal instillation ... -
Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
Hadrup, Niels; Knudsen, Kristina Bram; Berthing, Trine; Wolff, Henrik; Bengtson, Stefan; Kofoed, Christian; Espersen, Roall; Højgaard, Casper; Winther, Jakob Rahr; Willemoës, Martin; Wedin, Irene; Nuopponen, Markus; Alenius, Harri; Norppa, Hannu; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2019)We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE ... -
Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials. Inflammation and DNA strand breaks
Hadrup, Niels; Saber, Anne T.; Kyjovska, Zdenka O.; Jacobsen, Nicklas R.; Vippola, Minnamari; Sarlin, Essi; Ding, Yaobo; Schmid, Otmar; Wallin, Håkan; Jensen, Keld A. ; Vogel, Ulla (Peer reviewed; Journal article, 2019)Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 ... -
Safe-by-design strategies for lowering the genotoxicity and pulmonary inflammation of multiwalled carbon nanotubes: Reduction of length and the introduction of COOH groups
Hadrup, Niels; Knudsen, Kristina Bram; Carriere, Marie; Mayne-L'Hermite, Martine; Bobyk, Laure; Allard, Soline; Miserque, Frédéric; Pibaleau, Baptiste; Pinault, Mathieu; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2021)Potentially, the toxicity of multiwalled carbon nanotubes (MWCNTs) can be reduced in a safe-by-design strategy. We investigated if genotoxicity and pulmonary inflammation of MWCNTs from the same batch were lowered by a) ... -
Unchanged pulmonary toxicity of ZnO nanoparticles formulated in a liquid matrix for glass coating
Saber, Anne Thoustrup; Hadrup, Niels; Williams, Andrew; Mortensen, Alicja; Szarek, Józef; Kyjovska, Zdenka; Kurz, Alexander; Jacobsen, Nicklas Raun; Wallin, Håkan; Halappanavar, Sabina; Vogel, Ulla (Peer reviewed; Journal article, 2022)The inclusion of nanoparticles can increase the quality of certain products. One application is the inclusion of Zinc oxide (ZnO) nanoparticles in a glass coating matrix to produce a UV-absorbing coating for glass sheets. ...