Browsing Brage by Author "Haugen, Aage"
Now showing items 1-20 of 32
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A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences
Thorgeirsson, TE; Steinberg, S; Reginsson, GW; Bjornsdottir, G; Rafnar, T; Jonsdottir, I; Helgadottir, A; Gretarsdottir, S; Helgadottir, H; Jonsson, S; Matthiasson, SE; Gislason, T; Tyrfingsson, T; Gudbjartsson, T; Isaksson, HJ; Hardardottir, H; Sigvaldason, A; Kiemeney, LA; Haugen, Aage; Zienolddiny, Shanbeh; Wolf, HJ; Franklin, WA; Panadero, A; Mayordomo, JI; Hall, IP; Rönmark, E; Lundbäck, B; Dirksen, A; Ashraf, Haseem; Pedersen, JH; Masson, G; Sulem, P; Thorsteinsdottir, U; Gudbjartsson, DF; Stefansson, K (Peer reviewed; Journal article, 2016)Using Icelandic whole-genome sequence data and an imputation approach we searched for rare sequence variants in CHRNA4 and tested them for association with nicotine dependence. We show that carriers of a rare missense ... -
A Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts
Noro, Rintaro; Ishigame, Teruhide; Walsh, Naomi; Shiraishi, Kouya; Robles, Ana I.; Ryan, Bríd M.; Schetter, Aaron J.; Bowman, Elise D.; Welsh, Judith A.; Seike, Masahiro; Gemma, Akihiko; Skaug, Vidar; Mollerup, Steen Kristen; Haugen, Aage; Yokota, Jun; Kohno, Takashi; Harris, Curtis C. (Peer reviewed; Journal article, 2017)Introduction: There are no validated molecular methods that prospectively identify patients with surgically resected lung squamous cell carcinoma (SCC) at high risk for recurrence. By focusing on the expression of genes ... -
An integrated prognostic classifier for Stage I lung adenocarcinoma based on mRNA, microRNA, and DNA methylation biomarkers
Robles, Ana I.; Arai, Eri; Mathé, Ewy A.; Okayama, Hirokazu; Schetter, Aaron J.; Brown, Derek; Petersen, David; Bowman, Elise D.; Noro, Rintaro; Welsh, Judith A.; Edelman, Daniel C.; Stevenson, Holly S.; Wang, Yonghong; Tsuchiya, Naoto; Kohno, Takashi; Skaug, Vidar; Mollerup, Steen Kristen; Haugen, Aage; Meltzer, Paul S.; Yokota, Jun; Kanai, Yae; Harris, Curtis C. (Peer reviewed; Journal article, 2015)Introduction: Up to 30% stage I lung cancer patients suffer recurrence within 5 years of curative surgery. We sought to improve existing protein-coding gene and microRNA expression prognostic classifiers by incorporating ... -
Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations
Etokebe, Godfrey; Zienolddiny, Shanbeh; Kupanovac, Zeljko; Enersen, Morten; Balen, Sanja; Flego, Velkjo; Bulat-Kardum, Ljiljana; Radojčić-Badovinac, Anđelka; Skaug, Vidar; Bakke, Per S.; Haugen, Aage; Dembic, Zlatko (Journal article, 2015) -
Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaust
Rynning, Iselin; Arlt, Volker M.; Vrbova, Kristyna; Neca, Jiri; Rossner, Pavel; Klema, Jiri; Ulvestad, Bente; Petersen, Elisabeth; Skare, Øivind; Haugen, Aage; Phillips, David H.; Machala, Miroslav; Topinka, Jan; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2018)Objectives: This study aimed to assess the biological impact of occupational exposure to diesel exhaust (DE) including DE particles (DEP) from heavy-duty diesel-powered equipment in Norwegian tunnel finishing workers (TFW). ... -
CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis—A meta-analysis
Chen, Li-Shiun; Hung, Rayjean J.; Baker, Timothy B.; Horton, Amy; Culverhouse, Rob; Saccone, Nancy; Cheng, Iona; Deng, Bo; Han, Younghun; Hansen, Helen M.; Horsman, Janet; Kim, Claire; Lutz, Sharon; Rosenberger, Albert; Aben, Katja K.; Andrew, Angeline S.; Breslau, Naomi; Chang, Shen-Chih; Dieffenbach, Aida Karina; Dienemann, Hendrik; Frederiksen, Brittni; Han, Jiali; Hatsukami, Dorothy K.; Johnson, Eric O.; Pande, Mala; Wrensch, Margaret R.; McLaughlin, John R.; Skaug, Vidar; van der Heijden, Henricus F.; Wampfler, Jason; Wenzlaff, Angela; Woll, Penella; Zienolddiny, Shanbeh; Bickeböller, Heike; Brenner, Hermann; Duell, Eric J.; Haugen, Aage; Henrich, Joachim; Hokanson, John E.; Hunter, David J.; Kiemeney, Lambertus A.; Lazarus, Philip; Le Marchand, Loic; Liu, Geoffrey; Mayordomo, Jose; Risch, Angela; Schwartz, Ann G.; Teare, Dawn; Wu, Xifeng; Wiencke, John K.; Yang, Ping; Zhang, Zuo-Feng; Spitz, Margaret R.; Kraft, Peter; Amos, Christopher I.; Bierut, Laura J. (Peer reviewed; Journal article, 2015)Background: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 ... -
Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer
Samulin-Erdem, Johanna Maria; Arnoldussen, Yke Jildouw; Skaug, Vidar; Haugen, Aage; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2017)Metastasis and cell adhesion are key aspects of cancer progression. Neurofascin (NFASC) is a member of the immunoglobulin superfamily of adhesion molecules and, while studies on NFASC are inadequate, other members have ... -
CTCF mediates the TERT enhancer-promoter interactions in lung cancer cells: Identification of a novel enhancer region involved in the regulation of TERT gene
Eldholm, Vegard; Haugen, Aage; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2014)Telomerase activation is a hallmark of cancer. Although the regulation of the telomerase reverse transcriptase catalytic subunit (TERT), the rate‐limiting factor for telomerase activity, has been studied intensively it ... -
Effects of carbon nanotubes on intercellular communication and involvement of IL-1 genes
Arnoldussen, Yke Jildouw; Anmarkrud, Kristine Haugen; Skaug, Vidar; Apte, Ron N.; Haugen, Aage; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2016)An increasing amount of products containing engineered nanoparticles is emerging. Among these particles are carbon nanotubes (CNTs) which are of interest for a wide range of industrial and biomedical applications. There ... -
Elevated platelet count appears to be causally associated with increased risk of lung cancer. A Mendelian randomization analysis
Zhu, Ying; Wei, Yongyue; Zhang, Ruyang; Dong, Xuesi; Shen, Sipeng; Zhao, Yang; Bai, Jianling; Albanes, Demetrius; Caporaso, Neil E.; Landi, Maria Teresa; Zhu, Bin; Chanock, Stephen J.; Gu, Fangyi; Lam, Stephen; Ming-Sound, Tsao; Shepherd, Frances A.; Tardon, Adonina; Fernández-Somoano, Ana; Fernandez-Tardon, Guillermo; Chen, Chu; Barnett, Matthew J.; Doherty, Jennifer; Bojesen, Stig E.; Johansson, Mattias; Brennan, Paul; McKay, James D.; Carreras-Torres, Robert; Muley, Thomas; Risch, Angela; Wichmann, Heinz-Erich; Bickeboller, Heike; Rosenberger, Albert; Rennert, Gad; Saliba, Walid; Arnold, Susanne; Field, John K.; Davies, Michael P.A.; Marcus, Michael W.; Wu, Xifeng; Ye, Yuanqing; Le Marchand, Loic; Wilkens, Lynne R.; Melander, Olle; Manjer, Jonas; Brunnström, Hans; Hung, Rayjean J.; Liu, Geoffrey; Brhane, Yonathan; Kachuri, Linda; Andrew, Angeline S.; Duell, Eric J.; Kiemeney, Lambertus A.; van der Heijden, Erik H. F. M.; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Grankvist, Kjell; Johansson, Mikael; Woll, Penella; Cox, Angela; Taylor, Fiona; Teare, Dawn; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Houlston, Richard S.; McLaughlin, John; Stevens, Victoria L.; Shen, Hongbing; Hu, Zhibin; Dai, Juncheng; Amos, Christopher I.; Han, Younghun; Zhu, Dakai; Goodman, Gary E.; Chen, Feng; Christiani, David C. (Peer reviewed; Journal article, 2019)Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung ... -
Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cells
Bersaas, Audun Trygge Haugen; Arnoldussen, Yke Jildouw; Sjøberg, Mari; Haugen, Aage; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2016)Lung cancer is largely an environmentally caused disease with poor prognosis. An in vitro transformation model of human bronchial epithelial cells (HBEC) was used to study long-term effects of tobacco smoke carcinogens on ... -
Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report
Tekpli, Xavier; Skaug, Vidar; Bæra, Rita; Phillips, David H.; Haugen, Aage; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2016)Purpose: In the past, anomalous estrogen receptor (ER) regulation has been associated with various lung pathologies, but so far its involvement in lung cancer initiation and/or progression has remained unclear. Here, we ... -
Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
Ferreiro-Iglesias, Aida; Lesseur, Corina; McKay, James; Hung, Rayjean J.; Han, Younghun; Zong, Xuchen; Christiani, David; Johansson, Mattias; Xiao, Xiangjun; Li, Yafang; Qian, David C.; Ji, Xuemei; Liu, Geoffrey; Caporaso, Neil; Scelo, Ghislaine; Zaridze, David; Mukeriya, Anush; Kontic, Milica; Ognjanovic, Simona; Lissowska, Jolanta; Szołkowska, Małgorzata; Swiatkowska, Beata; Janout, Vladimir; Holcatova, Ivana; Bolca, Ciprian; Savic, Milan; Ognjanovic, Miodrag; Bojesen, Stig Egil; Wu, Xifeng; Albanes, Demetrios; Aldrich, Melinda C.; Tardon, Adonina; Fernandez-Somoano, Ana; Fernandez-Tardon, Guillermo; Le Marchand, Loic; Rennert, Gad; Chen, Chu; Doherty, Jennifer; Goodman, Gary; Bickeböller, Heike; Wichmann, H.-Erich; Risch, Angela; Rosenberger, Albert; Shen, Hongbing; Dai, Juncheng; Field, John K.; Davies, Michael; Woll, Penella; Teare, M. Dawn; Kiemeney, Lambertus A.; van der Heijden, Erik H.; Yuan, Jian-Min; Hong, Yun-Chul; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Tsao, Ming-Sound; Johansson, Mikael; Grankvist, Kjell; Schabath, Matthew B.; Andrew, Angeline; Duell, Eric; Melander, Olle; Brunnström, Hans; Lazarus, Philip; Arnold, Susanne; Slone, Stacey; Byun, Jinyoung; Kamal, Ahsan; Zhu, Dakai; Landi, Maria Teresa; Amos, Christopher I.; Brennan, Paul (Peer reviewed; Journal article, 2018) -
Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development
Li, Yafang; Xiao, Xiangjun; Bossé, Yohan; Gorlova, Olga; Gorlov, Ivan; Han, Younghun; Byun, Jinyoung; Leighl, Natasha; Johansen, Jakob S.; Barnett, Matt; Chen, Chu; Goodman, Gary; Cox, Angela; Taylor, Fiona; Woll, Penella; Wichmann, Erich; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Albert; Han, Jiali; Siminovitch, Katherine; Arnold, Susanne; Haura, Eric B.; Bolca, Ciprian; Holcátová, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolanta; Mukeria, Anush; Ognjanovic, Simona; Orlowski, Tadeusz M.; Scelo, Ghislaine; Swiatkowska, Beata; Zaridze, David; Bakke, Per S.; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, Eric J.; Butler, Lesley M.; Houlston, Richard; Artigas, Maria Soler; Grankvist, Kjell; Johansson, Mikael; Shepherd, Frances A.; Marcus, Michael; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, Antonia; Tumino, Rosaria; Liu, Geoffrey; Bojesen, Stig; Wu, Xifeng; Le Marchand, Loic; Albanes, Demetrios; Bickeböller, Heike; Aldrich, Melinda C.; Bush, William S.; Tardon, Adonina; Rennert, Gad; Teare, M. Dawn; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Bertazzi, Pier Alberto; Pesatori, Angela C.; Christiani, David C.; Caporaso, Neil; Johansson, Mattias; McKay, James D.; Brennan, Paul; Hung, Rayjean J.; Amos, Christopher I. (Journal article, 2019)The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterationsand tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the ... -
Genetic modifiers of radon-induced lung cancer risk. A genome-wide interaction study in former uranium miners
Rosenberger, Albert; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Haiman, C.A.; Albanes, Demetrios; Aldrich, Melinda; Tardon, Adonina; Fernandez-Tardon, G.; Rennert, Gad; Field, John K.; Kiemeney, B.; Lazarus, Philip; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Brunnsstöm, Hans; Goodman, Gary G.; Doherty, Jennifer A.; Chen, Chu; Teare, Dawn; Wichmann, H. Erich; Manz, Judith; Risch, Angela; Muley, Thomas R; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Amos, Christopher I.; Pesch, Beate; Johnen, Georg; Bruning, Thomas; Bickeboller, Heike; Gomolka, Maria (Peer reviewed; Journal article, 2018)Purpose: Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify ... -
Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis
Chen, Li-Shiun; Baker, Timothy; Hung, Rayjean J.; Horton, Amy; Culverhouse, Robert; Hartz, Sarah; Saccone, Nancy; Cheng, Iona; Deng, Bo; Han, Younghun; Hansen, Helen M.; Horsman, Janet; Kim, Claire; Rosenberger, Albert; Aben, Katja K.; Andrew, Angeline S.; Chang, Shen-Chih; Saum, Kai-Uwe; Dienemann, Hendrik; Hatsukami, Dorothy K.; Johnson, Eric O.; Pande, Mala; Wrensch, Margaret R.; McLaughlin, John; Skaug, Vidar; van der Heijden, Erik H.; Wenzlaff, Angela; Woll, Penella; Zienolddiny, Shanbeh; Bickeböller, Heike; Brenner, Hermann; Duell, Eric J.; Haugen, Aage; Brüske, Irene; Kiemeney, Lambertus A.; Lazarus, Philip; Le Marchand, Loic; Liu, Geoffrey; Mayardomo, Jose; Risch, Angela; Schwartz, Ann G.; Teare, M. Dawn; Wu, Xifeng; Wiencke, John K.; Yang, Ping; Zhang, Zuo-Feng; Spitz, Margaret R.; Amos, Christopher I.; Bierut, Laura J.; Bierut, Laura J (Peer reviewed; Journal article, 2016) -
Gene–gene interaction of AhRwith and within the Wntcascade afects susceptibility to lung cancer
Rosenberger, Albert; Muttray, Nils; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Aldrich, Melinda C.; Tardon, Adonina; Fernández‑Tardón, Guillermo; Rennert, Gad; Field, John K.; Davies, Michael P. A.; Liloglou, Triantafllos; Kiemeney, Lambertus A.; Lazarus, Philip; Wendel, Bernadette; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Duell, Eric J.; Arnold, Susanne M.; Goodman, Gary G.; Chen, Chu; Doherty, Jennifer A.; Taylor, Fiona; Cox, Angela; Voll, Penella J.; Risch, Angela; Muley, Thomas R.; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Shete, Sanjay S.; Amos, Christopher I.; Bickeboller, Heike (Peer reviewed; Journal article, 2022)Background: Aberrant Wnt signalling, regulating cell development and stemness, infuences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex ... -
Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population
Li, Y.; Xiao, X.; Han, Y.; Gorlova, O.; Qian, D.; Leigh, N.; Johansen, J.S.; Barnett, M.; Chen, C.; Goodman, G.; Cox, A.; Taylor, F.; Woll, P.; Wichmann, H.E.; Manz, J.; Muley, T.; Risch, A.; Rosenberger, A.; Arnold, S.M.; Haura, E.B.; Bolca, C.; Holcatova, I.; Janout, V.; Kontic, M.; Lissowska, J.; Mukeria, A.; Ognjanovic, S.; Orlowski, T.M.; Scelo, G.; Swiatkowska, B.; Zaridze, D.; Bakke, Per S.; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, E.J.; Butler, L.M.; Houlston, R.; Artigas, M.S.; Grankvist, K.; Johansson, M.; Shepherd, F.A.; Marcus, M.W.; Brunnström, H.; Manjer, J.; Melander, O.; Muller, D.C.; Overvad, K.; Trichopoulou, A.; Tumino, R.; Liu, G.; Bojesen, S.E.; Wu, X.; Le Marchand, L.; Albanes, D.; Bickeböller, H.; Aldric, M.C.; Bush, W.S.; Tardon, A.; Rennert, G.; Teare, M.D.; Field, J.K.; Kiemeney, L.A.; Lazarus, P.; Haugen, Aage; Lam, S.; Scabath, M.B.; Andrew, A.S.; Bertazzi, P.A.; Pesatori, A.C.; Christiani, D.C.; Caporaso, N.; Johansson, M.; McKay, J.D.; Brennan, P.; Hung, R.J.; Amos, C.I. (Peer reviewed; Journal article, 2017)Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide ... -
Helsefare ved produksjon og bruk av krom- kobber- arsen- (CCA)-impregnert trevirke
Ryberg, David; Haugen, Aage (HD; 1036/92, Research report, 1992) -
Iam hiQ - a novel pair of accuracy indices for imputed genotypes
Rosenberger, Albert; Tozzi, Viola; Bickeböller, Heike; Hung, Rayjean J.; Christiani, David C.; Caporaso, Neil E.; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Aldrich, Melinda C.; Tardon, Adonina; Fernandez-Tardon, Guillermo; Rennert, Gad; Field, John K.; Davies, Michael; Liloglou, Triantafillos; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Duell, Eric J.; Arnold, Susanne M.; Brunnström, Hans; Melander, Olle; Goodman, Gary E.; Chen, Chu; Doherty, Jennifer A.; Teare, M. Dawn; Cox, Angela; Woll, Penella J.; Risch, Angela; Muley, Thomas R.; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Shete, Sanjay S.; Amos, Christopher I. (Peer reviewed; Journal article, 2022)Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are ...