Browsing Brage by Author "Jackson, Petra"
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Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice
Hadrup, Niels; Rahmani, Feriel; Jacobsen, Nicklas R.; Saber, Anne T.; Jackson, Petra; Bengtson, Stefan; Williams, Andrew; Wallin, Håkan; Halappanavar, Sabina; Vogel, Ulla (Peer reviewed; Journal article, 2019)Inhalation of nanosized zinc oxide (ZnO) induces metal fume fever and systemic acute phase response in humans. Acute phase response activation is a cardiovascular risk factor; we investigated whether pulmonary exposure of ... -
Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: Investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles
Hadrup, Niels; Bengtson, Stefan; Jacobsen, Nicklas R. ; Jackson, Petra; Nocun, Marek ; Saber, Anne T.; Jensen, Keld A. ; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2017)Intratracheal instillation serves as a model for inhalation exposure. However, for this, materials are dispersed in appropriate media that may influence toxicity. We tested whether different intratracheal instillation ... -
Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity
Poulsen, Sarah S.; Jackson, Petra; Kling, Kirsten; Knudsen, Kristina B.; Skaug, Vidar; Kyjovska, Zdenka O.; Thomsen, Birthe L.; Clausen, Per A.; Atluri, Rambabu; Berthing, Trine; Bengtson, Stefan; Wolff, Henrik; Jensen, Keld A.; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2016)Lung deposition of multi-walled carbon nanotubes (MWCNT) induces pulmonary toxicity. Commercial MWCNT vary greatly in physicochemical properties and consequently in biological effects. To identify determinants of MWCNT-induced ... -
Physicochemical predictors of Multi‐Walled Carbon Nanotube‐induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different Multi‐Walled Carbon Nanotubes in mice
Knudsen, Kristina Bram; Berthing, Trine; Jackson, Petra; Poulsen, Sarah S.; Mortensen, Alicja; Jacobsen, Nicklas Raun; Skaug, Vidar; Szarek, Józef; Hougaard, Karin Sørig; Wollf, Henrik; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2018)Multi‐walled carbon nanotubes (MWCNT) are widely used nanomaterials that cause pulmonary toxicity upon inhalation. The physicochemical properties of MWCNT vary greatly, which makes general safety evaluation challenging to ... -
Ranking of nanomaterial potency to induce pathway perturbations associated with lung responses
Halappanavar, Sabina; Rahman, Luna; Nikota, Jake; Poulsen, Sarah S.; Ding, Yaobo; Jackson, Petra; Wallin, Håkan; Schmid, Otmar; Vogel, Ulla; Williams, Andrew (Peer reviewed; Journal article, 2019)Global transcriptomic responses in lungs of mice exposed for 24 h to individual multi-walled carbon nanotubes (MWCNTs, ten different types), nano titanium dioxide (nano TiO2, nine different types) and one type of carbon ...