Blar i Brage på forfatter "Knudsen, Kristina Bram"
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In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT
Di Ianni, Emilio; Samulin-Erdem, Johanna Maria; Møller, Peter; Sahlgren, Nicklas Mønster; Poulsen, Sarah Søs; Knudsen, Kristina Bram; Zienolddiny, Shanbeh; Saber, Anne Thoustrup; Wallin, Håkan; Vogel, Ulla; Jacobsen, Nicklas Raun (Peer reviewed; Journal article, 2021)Background Multi-walled carbon nanotubes (MWCNT) have received attention due to extraordinary properties, resulting in concerns for occupational health and safety. Costs and ethical concerns of animal testing drive a need ... -
Physicochemical predictors of Multi‐Walled Carbon Nanotube‐induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different Multi‐Walled Carbon Nanotubes in mice
Knudsen, Kristina Bram; Berthing, Trine; Jackson, Petra; Poulsen, Sarah S.; Mortensen, Alicja; Jacobsen, Nicklas Raun; Skaug, Vidar; Szarek, Józef; Hougaard, Karin Sørig; Wollf, Henrik; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2018)Multi‐walled carbon nanotubes (MWCNT) are widely used nanomaterials that cause pulmonary toxicity upon inhalation. The physicochemical properties of MWCNT vary greatly, which makes general safety evaluation challenging to ... -
Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure
Danielsen, Pernille Høgh; Poulsen, Sarah Søs; Knudsen, Kristina Bram; Clausen, Per Axel; Jensen, Keld Alstrup; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2024)Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 ... -
Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
Hadrup, Niels; Knudsen, Kristina Bram; Berthing, Trine; Wolff, Henrik; Bengtson, Stefan; Kofoed, Christian; Espersen, Roall; Højgaard, Casper; Winther, Jakob Rahr; Willemoës, Martin; Wedin, Irene; Nuopponen, Markus; Alenius, Harri; Norppa, Hannu; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2019)We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE ... -
Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure
Gaté, Laurent; Knudsen, Kristina Bram; Seidel, Carole; Berthing, Trine; Chézeau, Laëtitia; Jacobsen, Nicklas Raun; Valentino, Sarah; Wallin, Håkan; Bau, Sébastien; Wolff, Henrik; Sébillaud, Sylvie; Lorcin, Mylène; Grossmann, Stéphane; Viton, Stéphane; Nunge, Hervé; Darne, Christian; Vogel, Ulla; Cosnier, Frédéric (Peer reviewed; Journal article, 2019)Multi-walled carbon nanotubes (MWCNTs), which vary in length, diameter, functionalization and specific surface area, are used in diverse industrial processes. Since these nanomaterials have a high aspect ratio and are ... -
Safe-by-design strategies for lowering the genotoxicity and pulmonary inflammation of multiwalled carbon nanotubes: Reduction of length and the introduction of COOH groups
Hadrup, Niels; Knudsen, Kristina Bram; Carriere, Marie; Mayne-L'Hermite, Martine; Bobyk, Laure; Allard, Soline; Miserque, Frédéric; Pibaleau, Baptiste; Pinault, Mathieu; Wallin, Håkan; Vogel, Ulla (Peer reviewed; Journal article, 2021)Potentially, the toxicity of multiwalled carbon nanotubes (MWCNTs) can be reduced in a safe-by-design strategy. We investigated if genotoxicity and pulmonary inflammation of MWCNTs from the same batch were lowered by a) ... -
Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs
Solorio-Rodriguez, Silvia Aidee; Williams, Andrew; Poulsen, Sarah Søs; Knudsen, Kristina Bram; Jensen, Keld Alstrup; Clausen, Per Axel; Danielsen, Pernille Høgh; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina (Peer reviewed; Journal article, 2023)Single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) are nanomaterials with one or multiple layers of carbon sheets. While it is suggested that various properties influence their toxicity, the ...