Browsing Brage by Author "Krais, Annette M."

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    • Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism 

      Wohak, Laura E.; Krais, Annette M.; Kucab, Jill E.; Stertmann, Julia; Øvrebø, Steinar; Seidel, Albrecht; Phillips, David H.; Arlt, Volker M. (Peer reviewed; Journal article, 2016)
      The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation ...

    • Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer 

      Alhamdow, Ayman; Essig, Yona; Krais, Annette M.; Gustavsson, Per; Tinnerberg, Håkan; Lindh, Christian H.; Hagberg, Jessika; Graff, Pål; Albin, Maria; Broberg, Karin (Peer reviewed; Journal article, 2020)
      Objectives Exposure to high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) may cause cancer in chimney sweeps and creosote-exposed workers, however, knowledge about exposure to low-molecular-weight PAHs in relation ...