Browsing Brage by Author "Mollerup, Steen Kristen"
Now showing items 1-13 of 13
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A Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts
Noro, Rintaro; Ishigame, Teruhide; Walsh, Naomi; Shiraishi, Kouya; Robles, Ana I.; Ryan, Bríd M.; Schetter, Aaron J.; Bowman, Elise D.; Welsh, Judith A.; Seike, Masahiro; Gemma, Akihiko; Skaug, Vidar; Mollerup, Steen Kristen; Haugen, Aage; Yokota, Jun; Kohno, Takashi; Harris, Curtis C. (Peer reviewed; Journal article, 2017)Introduction: There are no validated molecular methods that prospectively identify patients with surgically resected lung squamous cell carcinoma (SCC) at high risk for recurrence. By focusing on the expression of genes ... -
An integrated prognostic classifier for Stage I lung adenocarcinoma based on mRNA, microRNA, and DNA methylation biomarkers
Robles, Ana I.; Arai, Eri; Mathé, Ewy A.; Okayama, Hirokazu; Schetter, Aaron J.; Brown, Derek; Petersen, David; Bowman, Elise D.; Noro, Rintaro; Welsh, Judith A.; Edelman, Daniel C.; Stevenson, Holly S.; Wang, Yonghong; Tsuchiya, Naoto; Kohno, Takashi; Skaug, Vidar; Mollerup, Steen Kristen; Haugen, Aage; Meltzer, Paul S.; Yokota, Jun; Kanai, Yae; Harris, Curtis C. (Peer reviewed; Journal article, 2015)Introduction: Up to 30% stage I lung cancer patients suffer recurrence within 5 years of curative surgery. We sought to improve existing protein-coding gene and microRNA expression prognostic classifiers by incorporating ... -
Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells
Marchetti, Sara; Mollerup, Steen Kristen; Gutzkow, Kristine Bjerve; Rizzi, Cristiana; Skuland, Tonje Schwach; Refsnes, Magne Arnold; Colombo, Anita; Øvrevik, Johan; Mantecca, Paride; Holme, Jørn Andreas (Peer reviewed; Journal article, 2021)Combustion-derived particles (CDPs), in particular from traffic, are regarded as a central contributor for adverse health effects linked to air pollution. Recently, also biomass burning has been recognized as an important ... -
Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaust
Rynning, Iselin; Arlt, Volker M.; Vrbova, Kristyna; Neca, Jiri; Rossner, Pavel; Klema, Jiri; Ulvestad, Bente; Petersen, Elisabeth; Skare, Øivind; Haugen, Aage; Phillips, David H.; Machala, Miroslav; Topinka, Jan; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2018)Objectives: This study aimed to assess the biological impact of occupational exposure to diesel exhaust (DE) including DE particles (DEP) from heavy-duty diesel-powered equipment in Norwegian tunnel finishing workers (TFW). ... -
Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes
Machala, Miroslav; Slavík, Josef; Kováč, Ondrej; Procházková, Jiřina; Pěnčíková, Kateřina; Pařenicová, Martina; Straková, Nicol; Kotouček, Jan; Kulich, Pavel; Mollerup, Steen Kristen; Vondráček, Jan; Hýžďalová, Martina (Peer reviewed; Journal article, 2021)Sphingolipids (SLs), glycosphingolipids (GSLs), and eicosanoids are bioactive lipids, which play important roles in the etiology of various diseases, including cancer. However, their content and roles in cancer cells, and ... -
Circulating miRNAs as molecular markers of occupational grain dust exposure
Straumfors, Anne; Duale, Nur; Foss, Oda Astrid Haarr; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2020)Dust from grain and feed production may cause adverse health effects in exposed workers. In this study we explored circulating miRNAs as potential biomarkers of occupational grain dust exposure. Twenty-two serum miRNAs ... -
Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cells
Bersaas, Audun Trygge Haugen; Arnoldussen, Yke Jildouw; Sjøberg, Mari; Haugen, Aage; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2016)Lung cancer is largely an environmentally caused disease with poor prognosis. An in vitro transformation model of human bronchial epithelial cells (HBEC) was used to study long-term effects of tobacco smoke carcinogens on ... -
Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report
Tekpli, Xavier; Skaug, Vidar; Bæra, Rita; Phillips, David H.; Haugen, Aage; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2016)Purpose: In the past, anomalous estrogen receptor (ER) regulation has been associated with various lung pathologies, but so far its involvement in lung cancer initiation and/or progression has remained unclear. Here, we ... -
In vitro transformation of human bronchial epithelial cells by diesel exhaust particles. Gene expression profiling and early toxic responses
Rynning, Iselin; Neca, Jiri; Vrbova, Kristyna; Libalova, Helena; Rossner, Pavel; Holme, Jørn Andreas; Gutzkow, Kristine Bjerve; Afanou, Anani K. Johnny; Arnoldussen, Yke Jildouw; Hruba, Eva; Skare, Øivind; Haugen, Aage; Topinka, Jan; Machala, Miroslav; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2018) -
Physico-chemical properties and biological effects of diesel and biomass particles
Longhin, Eleonora; Gualtieri, Maurizio; Capasso, Lauro; Bengalli, Rossella; Mollerup, Steen Kristen; Holme, Jørn Andreas; Øvrevik, Johan; Casadei, Simone; Di Benedetto, Christiano; Parenti, Paolo; Camatini, Marina (Peer reviewed; Journal article, 2016)Diesel combustion and solid biomass burning are the major sources of ultrafine particles (UFP) in urbanized areas. Cardiovascular and pulmonary diseases, including lung cancer, are possible outcomes of combustion particles ... -
The airborne mycobiome and associations with mycotoxins and inflammatory markers in the Norwegian grain industry
Straumfors, Anne; Mundra, Sunil; Foss, Oda Astrid Haarr; Mollerup, Steen Kristen; Kauserud, Håvard (Peer reviewed; Journal article, 2021)Grain dust exposure is associated with respiratory symptoms among grain industry workers. However, the fungal assemblage that contribute to airborne grain dust has been poorly studied. We characterized the airborne fungal ... -
The inhalable mycobiome of sawmill workers: Exposure characterization and diversity
Straumfors, Anne; Foss, Oda Astrid Haarr; Fuss, Janina; Mollerup, Steen Kristen; Kauserud, Håvard; Mundra, Sunil (Peer reviewed; Journal article, 2019)Exposure to fungal spores has been associated with respiratory symptoms and allergic alveolitis among sawmill workers, but the complexity of sawmill workers' fungal exposure has been poorly studied. We characterized the ... -
The role of SerpinB2 in human bronchial epithelial cells responses to particulate matter exposure
Longhin, E.; Camatini, M.; Bersaas, Audun Trygge Haugen; Mantecca, P.; Mollerup, Steen Kristen (Peer reviewed; Journal article, 2018)Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition ...