Browsing Brage by Author "Ropstad, Erik"
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A human exposure based mixture of persistent organic pollutants affects the stress response in female mice and their offspring
Hudecova, Alexandra Misci; Hansen, Kristine Eraker Aasland; Mandal, Siddhartha; Berntsen, Hanne Friis; Khezri, Abdolrahman; Bale, Tracy; Fraser, Thomas; Zimmer, Karin Elisabeth; Ropstad, Erik (Peer reviewed; Journal article, 2018)Persistent organic pollutants (POPs) are found in the food chain of both humans and animals and exert a wide spectrum of potentially adverse effects. The present experiment aimed to investigate whether a defined mixture ... -
A Human Relevant Defined Mixture of Persistent Organic Pollutants (POPs) Affects In Vitro Secretion of Glucagon-Like Peptide 1 (GLP-1), but Does not Affect Translocation of its Receptor
Shannon, Maeve; Xie, Yuling; Verhaegen, Steven; Wilson, Judie; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Connolly, Lisa; Green, Brian (Peer reviewed; Journal article, 2019)Environmental exposure to persistent organic pollutants (POPs) has been suggested as a contributing factor for the increased rate of T2D and obesity. A complex mixture of 29 POPs (Total mixture), based on human blood ... -
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro
Yadav, Ajay; Verhaegen, Steven; Verbruggen, Evelien; Kerhoas, Marie; Huiberts, Eva Henriëtte Willemijn; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Paulsen, Ragnhild Elisabeth (Peer reviewed; Journal article, 2021)Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were used to explore the effects on developmental neurotoxicity by a complex defined mixture of persistent organic pollutants (POPs). Its ... -
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Peer reviewed; Journal article, 2020)Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ... -
A human relevant mixture of persistent organic pollutants induces reactive oxygen species formation in isolated human leucocytes: Involvement of the β2-adrenergic receptor
Berntsen, Hanne Friis; Bodin, Johanna Eva; Øvrevik, Johan; Berntsen, Christopher Friis; Østby, Gunn Charlotte; Brinchmann, Bendik Christian; Ropstad, Erik; Myhre, Oddvar (Peer reviewed; Journal article, 2021)Exposure to chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) persistent organic pollutants (POPs) is associated with immunotoxicity and other adverse effects in humans and animals. Previous studies on POPs ... -
A human relevant mixture of persistent organic pollutants induces reactive oxygen species formation in isolated human leucocytes: Involvement of the β2-adrenergic receptor
Berntsen, Hanne Friis; Bodin, Johanna Eva; Øvrevik, Johan; Berntsen, Christopher Friis; Østby, Gunn Charlotte; Brinchmann, Bendik Christian; Ropstad, Erik; Myhre, Oddvar (Peer reviewed; Journal article, 2021)Exposure to chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) persistent organic pollutants (POPs) is associated with immunotoxicity and other adverse effects in humans and animals. Previous studies on POPs ... -
A human relevant mixture of persistent organic pollutants induces reactive oxygen species formation in isolated human leucocytes: Involvement of the β2-adrenergic receptor
Berntsen, Hanne Friis; Bodin, Johanna Eva; Øvrevik, Johan; Berntsen, Christopher Friis; Østby, Gunn Charlotte; Brinchmann, Bendik Christian; Ropstad, Erik; Myhre, Oddvar (Peer reviewed; Journal article, 2021)Exposure to chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) persistent organic pollutants (POPs) is associated with immunotoxicity and other adverse effects in humans and animals. Previous studies on POPs ... -
A mixture of Persistent Organic Pollutants (POPs) and Azoxymethane (AOM) show potential synergistic effects on intestinal tumorigenesis in the A/J Min/+ mouse model
Hansen, Kristine Eraker Aasland; Johanson, Silje Modahl; Steppeler, Christina; Sødring, Marianne Sundt; Østby, Gunn Charlotte; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Aleksandersen, Mona; Paulsen, Jan Erik; Ropstad, Erik (Peer reviewed; Journal article, 2018) -
A mixture of persistent organic pollutants relevant for human exposure inhibits the transactivation activity of the aryl hydrocarbon receptor in vitro
Doan, T.Q.; Berntsen, Hanne Friis; Verhaegen, Steven; Ropstad, Erik; Connolly, L.; Igout, A.; Muller, M.; Scippo, M.L. (Peer reviewed; Journal article, 2019)While humans are exposed to mixtures of persistent organic pollutants (POPs), their risk assessment isusually based on a chemical-by-chemical approach. To assess the health effects associated with mixedexposures, knowledge ... -
Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests. A small scale study
Hansen, Kristine Eraker Aasland; Hudecova, Alexandra Misci; Haugen, Fred; Skjerve, Eystein; Ropstad, Erik; Zimmer, Karin Elisabeth (Peer reviewed; Journal article, 2022)BACKGROUND All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J, ... -
Decreased macrophage phagocytic function due to xenobiotic exposures in vitro, difference in sensitivity between various macrophage models
Berntsen, Hanne Friis; Bølling, Anette Kocbach; Bjørklund, Cesilie Granum; Zimmer, Karin Elisabeth; Ropstad, Erik; Zienolddiny, Shanbeh; Becher, Rune; Holme, Jørn Andreas; Dirven, Hubert; Nygaard, Unni Cecilie; Bodin, Johanna Eva (Peer reviewed; Journal article, 2018)Both autoimmune disease prevalence and exposure to immunotoxic chemicals have increased the last decades. As a first screening of immunotoxic chemicals possibly affecting development of autoimmunity through attenuated ... -
Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro
Berntsen, Hanne Friis; Duale, Nur; Bjørklund, Cesilie Granum; Rangel-Huerta, Oscar Daniel; Dyrberg, Kine; Hofer, Tim; Rakkestad, Kirsten Eline; Østby, Gunn Charlotte; Halsne, Ruth; Boge, Gudrun Seeberg; Paulsen, Ragnhild Elisabeth; Myhre, Oddvar; Ropstad, Erik (Peer reviewed; Journal article, 2020)Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse neurobehaviour in humans and animals, and is observed to ... -
Effects of Defined Mixtures of Persistent Organic Pollutants (POPs) on Pre-lethal Cytotoxicity in the Human A-498 Kidney Cell Line In Vitro
Amber, Mazia; Xie, Yuling; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, Lisa (Peer reviewed; Journal article, 2021)A total mixture of 29 persistent organic pollutants (POPs) modelled from Scandinavian blood concentrations was used to expose human A-498 kidney cells for 24 h over a concentration range spanning below to above blood level ... -
Effects of defined mixtures of POPs and endocrine disruptors on the steroid metabolome of the human H295R adrenocortical cell line
Ahmed, Kareem Eldin Mohammed; Frøysa, Håvard G; Karlsen, Odd Andre; Blaser, Nello; Zimmer, Karin Elisabeth; Berntsen, Hanne Friis; Verhaegen, Steven; Ropstad, Erik; Kellmann, Ralf; Goksøyr, Anders (Peer reviewed; Journal article, 2018)The presence of environmental pollutants in our ecosystem may impose harmful health effects to wildlife and humans. Several of these toxic chemicals have a potential to interfere with the endocrine system. The adrenal ... -
Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo
Yadav, Ajay; Verhaegen, Steven; Filis, Panagiotis; Domanska, Diana; Lyle, Robert; Sundaram, Arvind; Leithaug, Magnus; Østby, Gunn Charlotte; Aleksandersen, Mona; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Fowler, Paul A.; Paulsen, Ragnhild Elisabeth Heimtun; Ropstad, Erik (Peer reviewed; Journal article, 2022)Prenatal exposure to persistent organic pollutants (POPs) is associated with neurodevelopmental disorders. In the present study, we explored whether a human-relevant POP mixture affects the development of chicken embryo ... -
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation
Davidsen, Nichlas; Lauvås, Anna Jacobsen; Myhre, Oddvar; Ropstad, Erik; Carpi, Donatella; Mendoza-de Gyves, Emilio; Berntsen, Hanne Friis; Dirven, Hubert; Paulsen, Ragnhild Elisabeth; Bal-Price, Anna; Pistollato, Francesca (Peer reviewed; Journal article, 2021)Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances (PFASs), brominated flame retardants (BFRs), organochlorine pesticides and polychlorinated biphenyls (PCBs) are known to cause cancer, ... -
Human blood-based exposure levels of persistent organic pollutant (POP)mixtures antagonise androgen receptor transactivation and translocation
McComb, J.; Mills, I.G.; Muller, M.; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, S. (Peer reviewed; Journal article, 2019)Introduction Human exposure to persistent organic pollutants (POPs) has been linked to genitourinary health-related conditions such as decreased sperm quality, hypospadias, and prostate cancer (PCa). Conventional risk ... -
Human‑based exposure levels of perfluoroalkyl acids may induce harmful effects to health by disrupting major components of androgen receptor signalling in vitro
McComb, J.; Mills, I.G.; Berntsen, Hanne Friis; Ropstad, Erik; Verhaegen, Steven; Connolly, L. (Peer reviewed; Journal article, 2019) -
Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes
Arnoldussen, Yke Jildouw; Skaug, Vidar; Aleksandersen, Mona; Ropstad, Erik; Anmarkrud, Kristine Haugen; Thornér, Elin Einarsdóttir; Lin, Fang-Chin; Bjørklund, Cesilie Granum; Kasem, Mayes; Eilertsen, Einar; Apte, Ron N.; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2018) -
Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes
Arnoldussen, Yke Jildouw; Skaug, Vidar; Aleksandersen, Mona; Ropstad, Erik; Anmarkrud, Kristine Haugen; Thornér, Elin Einarsdóttir; Lin, Fang-Chin; Bjørklund, Cesilie Granum; Kasem, Mayes; Ezzatpanah, Somayeh; Eilertsen, Einar; Apte, RN.; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2018)