Browsing Brage by Author "Sigvaldason, A"

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    • A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences 

      Thorgeirsson, TE; Steinberg, S; Reginsson, GW; Bjornsdottir, G; Rafnar, T; Jonsdottir, I; Helgadottir, A; Gretarsdottir, S; Helgadottir, H; Jonsson, S; Matthiasson, SE; Gislason, T; Tyrfingsson, T; Gudbjartsson, T; Isaksson, HJ; Hardardottir, H; Sigvaldason, A; Kiemeney, LA; Haugen, Aage; Zienolddiny, Shanbeh; Wolf, HJ; Franklin, WA; Panadero, A; Mayordomo, JI; Hall, IP; Rönmark, E; Lundbäck, B; Dirksen, A; Ashraf, Haseem; Pedersen, JH; Masson, G; Sulem, P; Thorsteinsdottir, U; Gudbjartsson, DF; Stefansson, K (Peer reviewed; Journal article, 2016)
      Using Icelandic whole-genome sequence data and an imputation approach we searched for rare sequence variants in CHRNA4 and tested them for association with nicotine dependence. We show that carriers of a rare missense ...