Browsing Brage by Author "Verhaegen, Steven"
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A Human Relevant Defined Mixture of Persistent Organic Pollutants (POPs) Affects In Vitro Secretion of Glucagon-Like Peptide 1 (GLP-1), but Does not Affect Translocation of its Receptor
Shannon, Maeve; Xie, Yuling; Verhaegen, Steven; Wilson, Judie; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Connolly, Lisa; Green, Brian (Peer reviewed; Journal article, 2019)Environmental exposure to persistent organic pollutants (POPs) has been suggested as a contributing factor for the increased rate of T2D and obesity. A complex mixture of 29 POPs (Total mixture), based on human blood ... -
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro
Yadav, Ajay; Verhaegen, Steven; Verbruggen, Evelien; Kerhoas, Marie; Huiberts, Eva Henriëtte Willemijn; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Paulsen, Ragnhild Elisabeth (Peer reviewed; Journal article, 2021)Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were used to explore the effects on developmental neurotoxicity by a complex defined mixture of persistent organic pollutants (POPs). Its ... -
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Peer reviewed; Journal article, 2020)Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ... -
A mixture of persistent organic pollutants relevant for human exposure inhibits the transactivation activity of the aryl hydrocarbon receptor in vitro
Doan, T.Q.; Berntsen, Hanne Friis; Verhaegen, Steven; Ropstad, Erik; Connolly, L.; Igout, A.; Muller, M.; Scippo, M.L. (Peer reviewed; Journal article, 2019)While humans are exposed to mixtures of persistent organic pollutants (POPs), their risk assessment isusually based on a chemical-by-chemical approach. To assess the health effects associated with mixedexposures, knowledge ... -
Effects of Defined Mixtures of Persistent Organic Pollutants (POPs) on Pre-lethal Cytotoxicity in the Human A-498 Kidney Cell Line In Vitro
Amber, Mazia; Xie, Yuling; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, Lisa (Peer reviewed; Journal article, 2021)A total mixture of 29 persistent organic pollutants (POPs) modelled from Scandinavian blood concentrations was used to expose human A-498 kidney cells for 24 h over a concentration range spanning below to above blood level ... -
Effects of defined mixtures of POPs and endocrine disruptors on the steroid metabolome of the human H295R adrenocortical cell line
Ahmed, Kareem Eldin Mohammed; Frøysa, Håvard G; Karlsen, Odd Andre; Blaser, Nello; Zimmer, Karin Elisabeth; Berntsen, Hanne Friis; Verhaegen, Steven; Ropstad, Erik; Kellmann, Ralf; Goksøyr, Anders (Peer reviewed; Journal article, 2018)The presence of environmental pollutants in our ecosystem may impose harmful health effects to wildlife and humans. Several of these toxic chemicals have a potential to interfere with the endocrine system. The adrenal ... -
Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo
Yadav, Ajay; Verhaegen, Steven; Filis, Panagiotis; Domanska, Diana; Lyle, Robert; Sundaram, Arvind; Leithaug, Magnus; Østby, Gunn Charlotte; Aleksandersen, Mona; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Fowler, Paul A.; Paulsen, Ragnhild Elisabeth Heimtun; Ropstad, Erik (Peer reviewed; Journal article, 2022)Prenatal exposure to persistent organic pollutants (POPs) is associated with neurodevelopmental disorders. In the present study, we explored whether a human-relevant POP mixture affects the development of chicken embryo ... -
Human blood-based exposure levels of persistent organic pollutant (POP)mixtures antagonise androgen receptor transactivation and translocation
McComb, J.; Mills, I.G.; Muller, M.; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, S. (Peer reviewed; Journal article, 2019)Introduction Human exposure to persistent organic pollutants (POPs) has been linked to genitourinary health-related conditions such as decreased sperm quality, hypospadias, and prostate cancer (PCa). Conventional risk ... -
Human‑based exposure levels of perfluoroalkyl acids may induce harmful effects to health by disrupting major components of androgen receptor signalling in vitro
McComb, J.; Mills, I.G.; Berntsen, Hanne Friis; Ropstad, Erik; Verhaegen, Steven; Connolly, L. (Peer reviewed; Journal article, 2019) -
Lipogenic Potency of Individual Perfuorinated Alkyl Acids (PFAAs) and Persistent Organic Pollutant (POP) Mixtures at Human Blood‑Based Exposure Levels on Adipogenesis in 3T3‑L1 Cells
Xie, Y.; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, L. (Peer reviewed; Journal article, 2021)In recent decades, the incidence of metabolic disorders has increased internationally. This increase has been linked to exposure to persistent organic pollutants (POPs), but little is known about the metabolic efects of ... -
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons
Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Peer reviewed; Journal article, 2020) -
Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice
Johanson, Silje Modahl; Ropstad, Erik; Østby, Gunn Charlotte; Aleksandersen, Mona; Zamaratskaia, Galia; Boge, Gudrun Seeberg; Halsne, Ruth; Trangerud, Cathrine; Lyche, Jan Ludvig; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Verhaegen, Steven (Peer reviewed; Journal article, 2021)The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the ... -
Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure
Yadav, Ajay; Verhaegen, Steven; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Berg, Vidar; Lyche, Jan Ludvig; Sabaredzovic, Azemira; Haug, Line Småstuen; Myhre, Oddvar; Zimmer, Karin Elisabeth; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Boix, Fernando (Peer reviewed; Journal article, 2021) -
PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons
Berntsen, Hanne Friis; Bjørklund, Cesilie Granum; Strandabø, Rønnaug; Haug, Trude; Moldes-Anaya, Angel; Fuentes-Lazaro, Judit; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Tasker, R. Andrew; Ropstad, Erik (Peer reviewed; Journal article, 2018) -
Time-dependent effects of perfluorinated compounds on viability in cerebellar granule neurons: Dependence on carbon chain length and functional group attached
Berntsen, Hanne Friis; Bjørklund, Cesilie Granum; Audinot, Jean-Nicolas; Hofer, Tim; Verhaegen, Steven; Lentzen, Esther; Gutleb, Arno; Ropstad, Erik (Peer reviewed; Journal article, 2017)The toxicity of long chained perfluoroalkyl acids (PFAAs) has previously been reported to be related to the length of the perfluorinated carbon chain and functional group attached. In the present study, we compared the ...