Browsing Brage by Author "Zienolddiny, Shanbeh"

Now showing items 1-20 of 59

    • A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells 

      Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Peer reviewed; Journal article, 2020)
      Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ...

    • A new efficient method to detect genetic interactions for lung cancer GWAS 

      Luyapan, Jennifer; Ji, Xuemei; Li, Siting; Xiao, Xiangjun; Zhu, Dakai; Duell, Eric J.; Christiani, David C.; Schabath, Matthew B.; Arnold, Susanne M.; Zienolddiny, Shanbeh; Brunnström, Hans; Melander, Olle; Thornquist, Mark D.; MacKenzie, Todd A.; Amos, Christopher I.; Gui, Jiang (Peer reviewed; Journal article, 2020)
      Background Genome-wide association studies (GWAS) have proven successful in predicting genetic risk of disease using single-locus models; however, identifying single nucleotide polymorphism (SNP) interactions at the ...

    • A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences 

      Thorgeirsson, TE; Steinberg, S; Reginsson, GW; Bjornsdottir, G; Rafnar, T; Jonsdottir, I; Helgadottir, A; Gretarsdottir, S; Helgadottir, H; Jonsson, S; Matthiasson, SE; Gislason, T; Tyrfingsson, T; Gudbjartsson, T; Isaksson, HJ; Hardardottir, H; Sigvaldason, A; Kiemeney, LA; Haugen, Aage; Zienolddiny, Shanbeh; Wolf, HJ; Franklin, WA; Panadero, A; Mayordomo, JI; Hall, IP; Rönmark, E; Lundbäck, B; Dirksen, A; Ashraf, Haseem; Pedersen, JH; Masson, G; Sulem, P; Thorsteinsdottir, U; Gudbjartsson, DF; Stefansson, K (Peer reviewed; Journal article, 2016)
      Using Icelandic whole-genome sequence data and an imputation approach we searched for rare sequence variants in CHRNA4 and tested them for association with nicotine dependence. We show that carriers of a rare missense ...

    • An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials 

      Bannuscher, Anne; Schmid, Otmar; Drasler, Barbara; Rohrbasser, Alain; Braakhuis, Hedwig M.; Meldrum, Kirsty; Zwart, Edwin P.; Gremmer, Eric R.; Birk, Barbara; Rissel, Manuel; Landsiedel, Robert; Moschini, Elisa; Evans, Stephen J.; Kumar, Pramod; Orak, Sezer; Doryab, Ali; Samulin-Erdem, Johanna Maria; Serchi, Tommaso; Vandebriel, Rob J.; Cassee, Flemming R.; Doak, Shareen H.; Petri-Fink, Alke; Zienolddiny, Shanbeh; Clift, Martin J.D.; Rothen-Rutishauser, Barbara (Peer reviewed; Journal article, 2022)
      Air-liquid interface (ALI) lung cell models cultured on permeable transwell inserts are increasingly used for respiratory hazard assessment requiring controlled aerosolization and deposition of any material on ALI cells. ...

    • Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model 

      Hung, Rayjean J.; Warkentin, Matthew T.; Brhane, Yonathan; Chatterjee, Nilanjan; Christiani, David C.; Landi, Maria Teresa; Caporaso, Neil E.; Liu, Geoffrey; Johansson, Mattias; Albanes, Demetrius; Le Marchand, Loic; Tardon, Adonina; Rennert, Gad; Bojesen, Stig E.; Chen, Chu; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Zienolddiny, Shanbeh; Lam, Stephen; Andrew, Angeline S.; Arnold, Susanne M.; Aldrich, Melinda C.; Bickeböller, Heike; Risch, Angela; Schabath, Matthew B.; McKay, James D.; Brennan, Paul; Amos, Christopher I. (Peer reviewed; Journal article, 2021)
      Lung cancer is the leading cause of cancer-related death globally. An improved risk stratification strategy can increase efficiency of low-dose CT (LDCT) screening. Here we assessed whether individual's genetic background ...

    • Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls 

      Wang, Yuzhuo; Gorlova, Olga Y.; Gorlov, Ivan P.; Zhu, Meng; Dai, Juncheng; Albanes, Demetrius; Lam, Stephen; Tardon, Adonina; Chen, Chu; Goodman, Gary E.; Bojesen, Stig E.; Landi, Maria Teresa; Johansson, Mattias; Risch, Angela; Wichmann, Heinz-Erich; Bickeboller, Heike; Christiani, David C.; Rennert, Gad; Arnold, Susanne M.; Brennan, Paul; Field, John K.; Shete, Sanjay; Le Marchand, Loïc; Melander, Olle; Brunnstrom, Hans; Liu, Geoffrey; Hung, Rayjean J.; Andrew, Angeline S.; Kiemeney, Lambertus A.; Zienolddiny, Shanbeh; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil E.; Woll, Penella J.; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Stevens, Victoria L.; Ma, Hongxia; Jin, Guangfu; Hu, Zhibin; Amos, Christopher I.; Shen, Hongbing (Peer reviewed; Journal article, 2020)
      Background: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been ...

    • Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations 

      Etokebe, Godfrey; Zienolddiny, Shanbeh; Kupanovac, Zeljko; Enersen, Morten; Balen, Sanja; Flego, Velkjo; Bulat-Kardum, Ljiljana; Radojčić-Badovinac, Anđelka; Skaug, Vidar; Bakke, Per S.; Haugen, Aage; Dembic, Zlatko (Journal article, 2015)

    • Cellular responses of human astrocytoma cells to dust from the Acheson process. An in vitro study 

      Arnoldussen, Yke Jildouw; Ervik, Torunn Kringlen; Berlinger, Balazs; Kero, Ida; Shaposhnikov, Sergey; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2017)
      Silicon carbide (SiC) is largely used in various products such as diesel particulate filters and solar panels. It is produced through the Acheson process where aerosolized fractions of SiC and other by-products are generated ...

    • Cellular Responses of Industrially Relevant Silica Dust on Human Glial Cells In Vitro 

      Arnoldussen, Yke Jildouw; Ervik, Torunn Kringlen; Eriksen, Mina Baarnes; Kero, Ida; Skaug, Vidar; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2019)
      Despite the rigorous emission control measures in the ferroalloy industry, there are still emissions of dust during the production of various alloys. Dust particles were collected from laboratory scale processes where oxide ...

    • Cellulose nanocrystals modulate alveolar macrophage phenotype and phagocytic function 

      Samulin-Erdem, Johanna Maria; Alswady-Hoff, Mayes; Ervik, Torunn Kringlen; Skare, Øivind; Ellingsen, Dag; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2019)
      Nanocellulose is a promising bio-nanomaterial with attractive properties suitable for multiple industrial applications. The increased use of nanocellulose may lead to occupational exposure and negative health outcomes. ...

    • Characterization and toxicity evaluation of air-borne particles released by grinding from twodental resin composites in vitro 

      Camassa, Laura Maria Azzurra; Ervik, Torunn Kringlen; Zegeye, Fikirte Debebe; Mdala, Ibrahimu; Valen, Håkon; Ansteinsson, Vibeke Elise; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2021)
      Objective The project aims to evaluate whether inhalation of particles released upon grinding of dental composites may pose a health hazard to dentists. The main objective of the study was to characterize the dust from ...

    • Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes 

      Phuyal, Santosh; Kasem, Mayes; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Vebraite, Vaineta; Shaposhnikov, Sergey; Slupphaug, Geir; Skaug, Vidar; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2018)
      The effects of long-term chronic exposure of human lung cells to multi-walled carbon nanotubes (MWCNT) and their impact upon cellular proteins and lipids were investigated. Since the lung is the major target organ, an in ...

    • CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis—A meta-analysis 

      Chen, Li-Shiun; Hung, Rayjean J.; Baker, Timothy B.; Horton, Amy; Culverhouse, Rob; Saccone, Nancy; Cheng, Iona; Deng, Bo; Han, Younghun; Hansen, Helen M.; Horsman, Janet; Kim, Claire; Lutz, Sharon; Rosenberger, Albert; Aben, Katja K.; Andrew, Angeline S.; Breslau, Naomi; Chang, Shen-Chih; Dieffenbach, Aida Karina; Dienemann, Hendrik; Frederiksen, Brittni; Han, Jiali; Hatsukami, Dorothy K.; Johnson, Eric O.; Pande, Mala; Wrensch, Margaret R.; McLaughlin, John R.; Skaug, Vidar; van der Heijden, Henricus F.; Wampfler, Jason; Wenzlaff, Angela; Woll, Penella; Zienolddiny, Shanbeh; Bickeböller, Heike; Brenner, Hermann; Duell, Eric J.; Haugen, Aage; Henrich, Joachim; Hokanson, John E.; Hunter, David J.; Kiemeney, Lambertus A.; Lazarus, Philip; Le Marchand, Loic; Liu, Geoffrey; Mayordomo, Jose; Risch, Angela; Schwartz, Ann G.; Teare, Dawn; Wu, Xifeng; Wiencke, John K.; Yang, Ping; Zhang, Zuo-Feng; Spitz, Margaret R.; Kraft, Peter; Amos, Christopher I.; Bierut, Laura J. (Peer reviewed; Journal article, 2015)
      Background: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 ...

    • Chrono-modulated effects of external stressors on oxidative stress and damage in humans: A scoping review on night shift work 

      Makris, Konstantinos C.; Heibati, Behzad; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2023)
      Background: Oxidative stress and tissue damage (OSD) play a pivotal role as an early-stage process in chronic disease pathogenesis. However, there has been little research to better understand the temporal (χρόνος[chronos]) ...

    • Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma 

      Qin, Na; Li, Yuancheng; Wang, Cheng; Zhu, Meng; Dai, Juncheng; Hong, Tongtong; Albanes, Demetrius; Lam, Stephen; Tardón, Adonina; Chen, Chu; Goodman, Gary; Bojesen, Stig E.; Landi, Maria Teresa; Johansson, Mattias; Risch, Angela; Wichmann, H-Erich; Bickeboller, Heike; Rennert, Gadi; Arnold, Susanne; Brennan, Paul; Field, John K.; Shete, Sanjay; Le Marchand, Loic; Melander, Olle; Brunnstrom, Hans; Liu, Geoffrey; Hung, Rayjean J.; Andrew, Angeline; Kiemeney, Lambertus A.; Zienolddiny, Shanbeh; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil; Woll, Penella; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Stevens, Victoria L.; Jin, Guangfu; Christiani, David C.; Hu, Zhibin; Amos, Christopher I.; Ma, Hongxia; Shen, Hongbing (Peer reviewed; Journal article, 2020)
      Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating ...

    • Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer 

      Samulin-Erdem, Johanna Maria; Arnoldussen, Yke Jildouw; Skaug, Vidar; Haugen, Aage; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2017)
      Metastasis and cell adhesion are key aspects of cancer progression. Neurofascin (NFASC) is a member of the immunoglobulin superfamily of adhesion molecules and, while studies on NFASC are inadequate, other members have ...

    • Criteria for grouping of manufactured nanomaterials to facilitate hazard and risk assessment, a systematic review of expert opinions. 

      Landvik, Nina Elisabeth; Skaug, Vidar; Mohr, Benedicte; Verbeek, Jos; Zienolddiny, Shanbeh (Journal article, 2018)
      With the emergence of nanotechnology the number of manufactured nanomaterials (MNM) in production and use is constantly increasing. Exposure of workers to MNM is of concern, because still much is unknown about health ...

    • CTCF mediates the TERT enhancer-promoter interactions in lung cancer cells: Identification of a novel enhancer region involved in the regulation of TERT gene 

      Eldholm, Vegard; Haugen, Aage; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2014)
      Telomerase activation is a hallmark of cancer. Although the regulation of the telomerase reverse transcriptase catalytic subunit (TERT), the rate‐limiting factor for telomerase activity, has been studied intensively it ...

    • Decreased macrophage phagocytic function due to xenobiotic exposures in vitro, difference in sensitivity between various macrophage models 

      Berntsen, Hanne Friis; Bølling, Anette Kocbach; Bjørklund, Cesilie Granum; Zimmer, Karin Elisabeth; Ropstad, Erik; Zienolddiny, Shanbeh; Becher, Rune; Holme, Jørn Andreas; Dirven, Hubert; Nygaard, Unni Cecilie; Bodin, Johanna Eva (Peer reviewed; Journal article, 2018)
      Both autoimmune disease prevalence and exposure to immunotoxic chemicals have increased the last decades. As a first screening of immunotoxic chemicals possibly affecting development of autoimmunity through attenuated ...

    • Effects of carbon nanotubes on intercellular communication and involvement of IL-1 genes 

      Arnoldussen, Yke Jildouw; Anmarkrud, Kristine Haugen; Skaug, Vidar; Apte, Ron N.; Haugen, Aage; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2016)
      An increasing amount of products containing engineered nanoparticles is emerging. Among these particles are carbon nanotubes (CNTs) which are of interest for a wide range of industrial and biomedical applications. There ...