Shared heritability and functional enrichment across six solid cancers
dc.contributor.author | Jiang, Xia | |
dc.contributor.author | Finucane, Hilary K. | |
dc.contributor.author | Schumacher, Fredrick R. | |
dc.contributor.author | Schmit, Stephanie L. | |
dc.contributor.author | Tyrer, Jonathan P. | |
dc.contributor.author | Han, Younghun | |
dc.contributor.author | Michailidou, Kyriaki | |
dc.contributor.author | Lesseur, Corina | |
dc.contributor.author | Kuchenbaecker, Karoline B. | |
dc.contributor.author | Dennis, Joe | |
dc.contributor.author | Conti, David V. | |
dc.contributor.author | Casey, Graham | |
dc.contributor.author | Gaudet, Mia M. | |
dc.contributor.author | Huyghe, Jeroen R. | |
dc.contributor.author | Albanes, Demetrius | |
dc.contributor.author | Aldrich, Melinda C. | |
dc.contributor.author | Andrew, Angeline S. | |
dc.contributor.author | Andrulis, Irene L. | |
dc.contributor.author | Anton-Culver, Hoda | |
dc.contributor.author | Antoniou, Antonis C. | |
dc.contributor.author | Antonenkova, Natalia N. | |
dc.contributor.author | Arnold, Susanne M. | |
dc.contributor.author | Aronsen, Kristan J. | |
dc.contributor.author | Arun, Banu K. | |
dc.contributor.author | Bandera, Elisa V. | |
dc.contributor.author | Barkardottir, Rosa B. | |
dc.contributor.author | Barnes, Daniel R. | |
dc.contributor.author | Batra, Jyotsna | |
dc.contributor.author | Beckmann, Matthias W. | |
dc.contributor.author | Benitez, Javier | |
dc.contributor.author | Benlloch, Sara | |
dc.contributor.author | Berchuck, Andrew | |
dc.contributor.author | Berndt, Sonja I. | |
dc.contributor.author | Bickeboller, Heike | |
dc.contributor.author | Bien, Stephanie A. | |
dc.contributor.author | Blomqvist, Carl | |
dc.contributor.author | Boccia, Stefania | |
dc.contributor.author | Bogdanova, Natalia V. | |
dc.contributor.author | Bojesen, Stig E. | |
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dc.contributor.author | Brenton, James D. | |
dc.contributor.author | Brook, Mark N. | |
dc.contributor.author | Brunet, Joan | |
dc.contributor.author | Brunnström, Hans | |
dc.contributor.author | Buchanan, Daniel D. | |
dc.contributor.author | Burwinkel, Barbara | |
dc.contributor.author | Butzow, Ralf | |
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dc.contributor.author | Caldés, Trinidad | |
dc.contributor.author | Caligo, Maria A. | |
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dc.contributor.author | Yannoukakos, Drakoulis | |
dc.contributor.author | Zheng, Wei | |
dc.contributor.author | Zienolddiny, Shanbeh | |
dc.contributor.author | Ziogas, Argyrios | |
dc.contributor.author | Zorn, Kristin K. | |
dc.contributor.author | Lane, Jacqueline M. | |
dc.contributor.author | Saxena, Richa | |
dc.contributor.author | Thomas, Duncan | |
dc.contributor.author | Hung, Rayjean J. | |
dc.contributor.author | Diergaarde, Brenda | |
dc.contributor.author | McKay, James | |
dc.contributor.author | Peters, Ulrike | |
dc.contributor.author | Hsu, Li | |
dc.contributor.author | García-Closas, Montserrat | |
dc.contributor.author | Eeles, Rosalind A. | |
dc.contributor.author | Chenevix-Trench, Georgia | |
dc.contributor.author | Brennan, Paul J. | |
dc.contributor.author | Haiman, Christopher A. | |
dc.contributor.author | Simard, Jacques | |
dc.contributor.author | Easton, Douglas F. | |
dc.contributor.author | Gruber, Stephen B. | |
dc.contributor.author | Pharoah, Paul D.P. | |
dc.contributor.author | Price, Alkes L. | |
dc.contributor.author | Pasaniuc, Bogdan | |
dc.contributor.author | Amos, Christopher I. | |
dc.contributor.author | Kraft, Peter | |
dc.contributor.author | Lindström, Sara | |
dc.date.accessioned | 2022-04-25T10:50:06Z | |
dc.date.available | 2022-04-25T10:50:06Z | |
dc.date.created | 2019-02-06T12:14:27Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Nature Communications. 2019, 10:431 1-23. | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/11250/2992489 | |
dc.description.abstract | Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. | |
dc.language.iso | eng | |
dc.title | Shared heritability and functional enrichment across six solid cancers | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | |
dc.source.pagenumber | 1-23 | |
dc.source.volume | 10:431 | |
dc.source.journal | Nature Communications | |
dc.identifier.doi | 10.1038/s41467-018-08054-4 | |
dc.identifier.cristin | 1673997 | |
cristin.unitcode | 7476,0,0,0 | |
cristin.unitname | Statens arbeidsmiljøinstitutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 |