dc.contributor.author | Hadrup, Niels | |
dc.contributor.author | Knudsen, Kristina Bram | |
dc.contributor.author | Carriere, Marie | |
dc.contributor.author | Mayne-L'Hermite, Martine | |
dc.contributor.author | Bobyk, Laure | |
dc.contributor.author | Allard, Soline | |
dc.contributor.author | Miserque, Frédéric | |
dc.contributor.author | Pibaleau, Baptiste | |
dc.contributor.author | Pinault, Mathieu | |
dc.contributor.author | Wallin, Håkan | |
dc.contributor.author | Vogel, Ulla | |
dc.date.accessioned | 2024-08-16T06:05:40Z | |
dc.date.available | 2024-08-16T06:05:40Z | |
dc.date.created | 2021-08-10T10:00:21Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1382-6689 | |
dc.identifier.uri | https://hdl.handle.net/11250/3146708 | |
dc.description.abstract | Potentially, the toxicity of multiwalled carbon nanotubes (MWCNTs) can be reduced in a safe-by-design strategy. We investigated if genotoxicity and pulmonary inflammation of MWCNTs from the same batch were lowered by a) reducing length and b) introducing COOH-groups into the structure. Mice were administered: 1) long and pristine MWCNT (CNT-long) (3.9 μm); 2) short and pristine CNT (CNT-short) (1 μm); 3) CNT modified with high ratio COOH-groups (CNT-COOH-high); 4) CNT modified with low ratio COOH-groups (CNT-COOH-low). MWCNTs were dosed by intratracheal instillation at 18 or 54 μg/mouse (∼0.9 and 2.7 mg/kg bw). Neutrophils numbers were highest after CNT-long exposure, and both shortening the MWCNT and addition of COOH-groups lowered pulmonary inflammation (day 1 and 28). Likewise, CNT-long induced genotoxicity, which was absent with CNT-short and after introduction of COOH groups. In conclusion, genotoxicity and pulmonary inflammation of MWCNTs were lowered, but not eliminated, by shortening the fibres or introducing COOH-groups. | |
dc.description.abstract | Safe-by-design strategies for lowering the genotoxicity and pulmonary inflammation of multiwalled carbon nanotubes: Reduction of length and the introduction of COOH groups | |
dc.language.iso | eng | |
dc.title | Safe-by-design strategies for lowering the genotoxicity and pulmonary inflammation of multiwalled carbon nanotubes: Reduction of length and the introduction of COOH groups | |
dc.title.alternative | Safe-by-design strategies for lowering the genotoxicity and pulmonary inflammation of multiwalled carbon nanotubes: Reduction of length and the introduction of COOH groups | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | |
dc.source.volume | 87 | |
dc.source.journal | Environmental Toxicology and Pharmacology | |
dc.identifier.doi | 10.1016/j.etap.2021.103702 | |
dc.identifier.cristin | 1924914 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |