dc.contributor.author | Forsberg, June Thorvaldsen | |
dc.contributor.author | Gjerstad, Johannes | |
dc.contributor.author | Flaten, Magne | |
dc.contributor.author | Aslaksen, Per M. | |
dc.date.accessioned | 2024-08-29T07:17:07Z | |
dc.date.available | 2024-08-29T07:17:07Z | |
dc.date.created | 2017-09-29T12:51:52Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Pain. 2018, 159 (1), 168-174. | |
dc.identifier.issn | 0304-3959 | |
dc.identifier.uri | https://hdl.handle.net/11250/3148960 | |
dc.description.abstract | Higher levels of fear have been shown to partly explain individual differences in placebo analgesic responding. The catechol-Omethyltransferase (COMT) rs4680 Val158Met polymorphism has been associated with both increased placebo analgesia and increased fear-related behavior, in what appears to be inconsistent findings in the literature. The aim of the study was therefore to investigate placebo analgesia and fear-related processes with regard to the COMT genotype, to sort out whether the Met-allele is associated with increased placebo analgesia or increased fear of pain (FOP). A 3 Group (Emla, placebo and natural history) by 5 Test (2 pretest, 3 posttests) mixed design was used (N 5 223). A contact heat-evoked stimulator was used to induce pain, and FOP was quantified with the Fear of Pain Questionnaire-III. Saliva was obtained for genotyping. As expected, we observed a significant interaction of test by group (P , 0.01), with lower pain report in the placebo group compared with the natural history group (P , 0.01). There was a main effect of the COMT genotype on fear of medical pain (P 5 0.032), and Met-allele carriers reported significantly higher fear of medical pain compared with the Val-allele (P 5 0.044). We observed no effect of the COMT genotype on mean pain-level report or placebo analgesia. Thus, we conclude that the Met-allele seems to be associated with the negative emotional process of fear, but not with placebo analgesia. | |
dc.description.abstract | Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia | |
dc.language.iso | eng | |
dc.title | Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia | |
dc.title.alternative | Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | |
dc.source.pagenumber | 168-174 | |
dc.source.volume | 159 | |
dc.source.journal | Pain | |
dc.source.issue | 1 | |
dc.identifier.doi | 10.1097/j.pain.0000000000001081 | |
dc.identifier.cristin | 1500410 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |