dc.contributor.author | Ellingsen, Dag | |
dc.contributor.author | Seljeflot, Ingebjørg | |
dc.contributor.author | Thomassen, Yngvar | |
dc.contributor.author | Thomassen, Magny Sissel S. | |
dc.contributor.author | Bakke, Berit | |
dc.contributor.author | Ulvestad, Bente | |
dc.date.accessioned | 2024-08-30T07:55:40Z | |
dc.date.available | 2024-08-30T07:55:40Z | |
dc.date.created | 2017-03-06T14:43:55Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | International Archives of Occupational and Environmental Health. 2017, 90 (4), 309-317. | |
dc.identifier.issn | 0340-0131 | |
dc.identifier.uri | https://hdl.handle.net/11250/3149217 | |
dc.description.abstract | Objectives: The aims were to study biomarkers of systemic inflammation, platelet/endothelial activation and thrombosis in tunnel construction workers (TCW). Methods: Biomarkers and blood fatty acids were measured in blood of 90 TCW and 50 referents before (baseline) and towards the end (follow-up) of a 12 days work period. They had been absent from work for 9 days at baseline. Air samples were collected by personal sampling. Results: Personal thoracic air samples showed geometric mean (GM) particulate matter and α-quartz concentrations of 604 and 74 µg/m3, respectively. The arithmetic mean (AM) concentration of elemental carbon was 51 µg/m3. The GM (and 95% confidence interval) concentration of the pro-inflammatory cytokine TNF-α decreased from 2.2 (2.0–2.4) at baseline to 2.0 pg/mL (1.8–2.2) (p = 0.02) at follow-up among the TCW. Also the platelet activation biomarkers P-selectin and CD40L decreased significantly [25.4 (24.1–26.6) to 24.4 (22.9–26.0)] ng/mL, p = 0.04 and 125 (114–137) to 105 (96–115) pg/mL, p < 0.001, respectively. ICAM-1 concentrations increased from 249 (238–260) to 254 (243–266) ng/mL (p = 0.02). No significant alterations were observed among the referents when assessed by paired sample t test. Unbeneficial alterations in blood fatty acid composition were observed between baseline and follow-up, mainly among referents. Conclusions: TCW had slightly reduced systemic inflammation and platelet activation although highly exposed to particulate matter, α-quarz and diesel exhaust, which might be due to increased physical activity during the exposure period. The slightly increased ICAM-1 may indicate monocyte recruitment to the lungs. The diet was substantially altered towards a less beneficial fatty acid profile. | |
dc.description.abstract | Biomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants | |
dc.language.iso | eng | |
dc.title | Biomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants | |
dc.title.alternative | Biomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | |
dc.source.pagenumber | 309-317 | |
dc.source.volume | 90 | |
dc.source.journal | International Archives of Occupational and Environmental Health | |
dc.source.issue | 4 | |
dc.identifier.doi | 10.1007/s00420-017-1199-x | |
dc.identifier.cristin | 1456056 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |