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dc.contributor.authorEllingsen, Dag
dc.contributor.authorSeljeflot, Ingebjørg
dc.contributor.authorThomassen, Yngvar
dc.contributor.authorThomassen, Magny Sissel S.
dc.contributor.authorBakke, Berit
dc.contributor.authorUlvestad, Bente
dc.date.accessioned2024-08-30T07:55:40Z
dc.date.available2024-08-30T07:55:40Z
dc.date.created2017-03-06T14:43:55Z
dc.date.issued2017
dc.identifier.citationInternational Archives of Occupational and Environmental Health. 2017, 90 (4), 309-317.
dc.identifier.issn0340-0131
dc.identifier.urihttps://hdl.handle.net/11250/3149217
dc.description.abstractObjectives: The aims were to study biomarkers of systemic inflammation, platelet/endothelial activation and thrombosis in tunnel construction workers (TCW). Methods: Biomarkers and blood fatty acids were measured in blood of 90 TCW and 50 referents before (baseline) and towards the end (follow-up) of a 12 days work period. They had been absent from work for 9 days at baseline. Air samples were collected by personal sampling. Results: Personal thoracic air samples showed geometric mean (GM) particulate matter and α-quartz concentrations of 604 and 74 µg/m3, respectively. The arithmetic mean (AM) concentration of elemental carbon was 51 µg/m3. The GM (and 95% confidence interval) concentration of the pro-inflammatory cytokine TNF-α decreased from 2.2 (2.0–2.4) at baseline to 2.0 pg/mL (1.8–2.2) (p = 0.02) at follow-up among the TCW. Also the platelet activation biomarkers P-selectin and CD40L decreased significantly [25.4 (24.1–26.6) to 24.4 (22.9–26.0)] ng/mL, p = 0.04 and 125 (114–137) to 105 (96–115) pg/mL, p < 0.001, respectively. ICAM-1 concentrations increased from 249 (238–260) to 254 (243–266) ng/mL (p = 0.02). No significant alterations were observed among the referents when assessed by paired sample t test. Unbeneficial alterations in blood fatty acid composition were observed between baseline and follow-up, mainly among referents. Conclusions: TCW had slightly reduced systemic inflammation and platelet activation although highly exposed to particulate matter, α-quarz and diesel exhaust, which might be due to increased physical activity during the exposure period. The slightly increased ICAM-1 may indicate monocyte recruitment to the lungs. The diet was substantially altered towards a less beneficial fatty acid profile.
dc.description.abstractBiomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants
dc.language.isoeng
dc.titleBiomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants
dc.title.alternativeBiomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber309-317
dc.source.volume90
dc.source.journalInternational Archives of Occupational and Environmental Health
dc.source.issue4
dc.identifier.doi10.1007/s00420-017-1199-x
dc.identifier.cristin1456056
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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