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dc.contributor.authorSamulin-Erdem, Johanna Maria
dc.contributor.authorNotø, Heidi Ødegaard
dc.contributor.authorSkare, Øivind
dc.contributor.authorLie, Jenny-Anne Sigstad
dc.contributor.authorPetersen-Øverleir, Marte
dc.contributor.authorReszka, Edyta
dc.contributor.authorPeplonska, Beata
dc.contributor.authorZienolddiny, Shanbeh
dc.date.accessioned2024-09-02T09:50:20Z
dc.date.available2024-09-02T09:50:20Z
dc.date.created2017-08-02T12:40:07Z
dc.date.issued2017
dc.identifier.citationCancer Medicine. 2017, 6 (8), 1988-1987.
dc.identifier.issn2045-7634
dc.identifier.urihttps://hdl.handle.net/11250/3149601
dc.description.abstractOccupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to increased breast cancer risk. Circadian disruption may also affect telomere length (TL). While short TL generally is associated with increased cancer risk, its association with breast cancer risk is inconclusive. We suggest that working schedules might be an important factor in assessment of effects of TL on breast cancer risk. Moreover, telomere shortening might be a potential mechanism for night work‐related breast cancer. In this study, effects of shift work on TL and its association with breast cancer risk were investigated in a nested breast cancer case–control study of Norwegian nurses. TL was assessed by qPCR in DNA from 563 breast cancer patients and 619 controls. Here, we demonstrate that TL is affected by intensive night work schedules, as work with six consecutive night for a period of more than 5 years was associated with decreased telomere lengths (−3.18, 95% CI: −6.46 to −0.58, P = 0.016). Furthermore, telomere shortening is associated with increased breast cancer risk in workers with long periods of consecutive night shifts. Thus, nurses with longer telomere lengths had a lower risk for breast cancer if they had worked more than four (OR: 0.37, 95% CI: 0.16–0.79, P = 0.014) or five (OR: 0.31, 95% CI: 0.10–0.83, P = 0.029) consecutive night shifts for a period of 5 years or more. These data suggest that telomere shortening is associated with the duration and intensity of night work and may be a contributing factor for breast cancer risk among female shift workers.
dc.description.abstractMechanisms of breast cancer risk in shift workers. Association of telomere shortening with the duration and intensity of night work
dc.language.isoeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMechanisms of breast cancer risk in shift workers. Association of telomere shortening with the duration and intensity of night work
dc.title.alternativeMechanisms of breast cancer risk in shift workers. Association of telomere shortening with the duration and intensity of night work
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.description.versionpublishedVersion
dc.source.pagenumber1988-1987
dc.source.volume6
dc.source.journalCancer Medicine
dc.source.issue8
dc.identifier.doi10.1002/cam4.1135
dc.identifier.cristin1483824
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International