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dc.contributor.authorNoro, Rintaro
dc.contributor.authorIshigame, Teruhide
dc.contributor.authorWalsh, Naomi
dc.contributor.authorShiraishi, Kouya
dc.contributor.authorRobles, Ana I.
dc.contributor.authorRyan, Bríd M.
dc.contributor.authorSchetter, Aaron J.
dc.contributor.authorBowman, Elise D.
dc.contributor.authorWelsh, Judith A.
dc.contributor.authorSeike, Masahiro
dc.contributor.authorGemma, Akihiko
dc.contributor.authorSkaug, Vidar
dc.contributor.authorMollerup, Steen Kristen
dc.contributor.authorHaugen, Aage
dc.contributor.authorYokota, Jun
dc.contributor.authorKohno, Takashi
dc.contributor.authorHarris, Curtis C.
dc.date.accessioned2024-09-02T09:56:38Z
dc.date.available2024-09-02T09:56:38Z
dc.date.created2016-09-12T11:03:51Z
dc.date.issued2017
dc.identifier.citationJournal of Thoracic Oncology. 2017, 12 (1), 65-76.
dc.identifier.issn1556-0864
dc.identifier.urihttps://hdl.handle.net/11250/3149608
dc.description.abstractIntroduction: There are no validated molecular methods that prospectively identify patients with surgically resected lung squamous cell carcinoma (SCC) at high risk for recurrence. By focusing on the expression of genes with known functions in development of lung SCC and prognosis, we sought to develop a robust prognostic classifier of early-stage lung SCC. Methods: The expression of 253 genes selected by literature search was evaluated in microarrays from 107 stage I/II tumors. Associations with survival were evaluated by Cox regression and Kaplan-Meier survival analyses in two independent cohorts of 121 and 91 patients with SCC, respectively. A classifier score based on multivariable Cox regression was derived and examined in six additional publicly available data sets of stage I/II lung SCC expression profiles (n = 358). The prognostic value of this classifier was evaluated in meta-analysis of patients with stage I/II (n = 479) and stage I (n = 326) lung SCC. Results: Dual specificity phosphatase 6 gene (DUSP6) and actinin alpha 4 gene (ACTN4) were associated with prognostic outcome in two independent patient cohorts. Their expression values were utilized to develop a classifier that identified patients with stage I/II lung SCC at high risk for recurrence (hazard ratio [HR] = 4.7, p = 0.018) or cancer-specific mortality (HR = 3.5, p = 0.016). This classifier also identified patients at high risk for recurrence (HR = 2.7, p = 0.008) or death (HR = 2.2, p = 0.001) in publicly available data sets of stage I/II and in meta-analysis of stage I patients. Conclusions: We have established and validated a prognostic classifier to inform clinical management of patients with lung SCC after surgical resection.
dc.description.abstractA Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts
dc.language.isoeng
dc.titleA Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts
dc.title.alternativeA Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber65-76
dc.source.volume12
dc.source.journalJournal of Thoracic Oncology
dc.source.issue1
dc.identifier.doi10.1016/j.jtho.2016.08.141
dc.identifier.cristin1380244
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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