Browsing Brage by Author "Manjer, Jonas"

Now showing items 1-7 of 7

    • Elevated platelet count appears to be causally associated with increased risk of lung cancer. A Mendelian randomization analysis 

      Zhu, Ying; Wei, Yongyue; Zhang, Ruyang; Dong, Xuesi; Shen, Sipeng; Zhao, Yang; Bai, Jianling; Albanes, Demetrius; Caporaso, Neil E.; Landi, Maria Teresa; Zhu, Bin; Chanock, Stephen J.; Gu, Fangyi; Lam, Stephen; Ming-Sound, Tsao; Shepherd, Frances A.; Tardon, Adonina; Fernández-Somoano, Ana; Fernandez-Tardon, Guillermo; Chen, Chu; Barnett, Matthew J.; Doherty, Jennifer; Bojesen, Stig E.; Johansson, Mattias; Brennan, Paul; McKay, James D.; Carreras-Torres, Robert; Muley, Thomas; Risch, Angela; Wichmann, Heinz-Erich; Bickeboller, Heike; Rosenberger, Albert; Rennert, Gad; Saliba, Walid; Arnold, Susanne; Field, John K.; Davies, Michael P.A.; Marcus, Michael W.; Wu, Xifeng; Ye, Yuanqing; Le Marchand, Loic; Wilkens, Lynne R.; Melander, Olle; Manjer, Jonas; Brunnström, Hans; Hung, Rayjean J.; Liu, Geoffrey; Brhane, Yonathan; Kachuri, Linda; Andrew, Angeline S.; Duell, Eric J.; Kiemeney, Lambertus A.; van der Heijden, Erik H. F. M.; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Grankvist, Kjell; Johansson, Mikael; Woll, Penella; Cox, Angela; Taylor, Fiona; Teare, Dawn; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Houlston, Richard S.; McLaughlin, John; Stevens, Victoria L.; Shen, Hongbing; Hu, Zhibin; Dai, Juncheng; Amos, Christopher I.; Han, Younghun; Zhu, Dakai; Goodman, Gary E.; Chen, Feng; Christiani, David C. (Peer reviewed; Journal article, 2019)
      Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung ...

    • Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development 

      Li, Yafang; Xiao, Xiangjun; Bossé, Yohan; Gorlova, Olga; Gorlov, Ivan; Han, Younghun; Byun, Jinyoung; Leighl, Natasha; Johansen, Jakob S.; Barnett, Matt; Chen, Chu; Goodman, Gary; Cox, Angela; Taylor, Fiona; Woll, Penella; Wichmann, Erich; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Albert; Han, Jiali; Siminovitch, Katherine; Arnold, Susanne; Haura, Eric B.; Bolca, Ciprian; Holcátová, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolanta; Mukeria, Anush; Ognjanovic, Simona; Orlowski, Tadeusz M.; Scelo, Ghislaine; Swiatkowska, Beata; Zaridze, David; Bakke, Per S.; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, Eric J.; Butler, Lesley M.; Houlston, Richard; Artigas, Maria Soler; Grankvist, Kjell; Johansson, Mikael; Shepherd, Frances A.; Marcus, Michael; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, Antonia; Tumino, Rosaria; Liu, Geoffrey; Bojesen, Stig; Wu, Xifeng; Le Marchand, Loic; Albanes, Demetrios; Bickeböller, Heike; Aldrich, Melinda C.; Bush, William S.; Tardon, Adonina; Rennert, Gad; Teare, M. Dawn; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Bertazzi, Pier Alberto; Pesatori, Angela C.; Christiani, David C.; Caporaso, Neil; Johansson, Mattias; McKay, James D.; Brennan, Paul; Hung, Rayjean J.; Amos, Christopher I. (Journal article, 2019)
      The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterationsand tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the ...

    • Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk 

      Ji, Xuemei; Bossé, Yohan; Landi, Maria Teresa; Gui, Jiang; Xiao, Xiangjun; Qian, David C; Joubert, Philippe; Lamontagne, Maxime; Li, Yafang; Gorlov, Ivan; de Biasi, Mariella; Han, Younghun; Gorlova, Olga; Hung, Rayjean J.; Wu, Xifeng; McKay, James; Zong, Xuchen; Carreras-Torres, Robert; Christiani, David C.; Caporaso, Neil; Johansson, Mattias; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loic; Albanes, Demetrios; Bickeboller, Heike; Aldrich, Melinda C.; Bush, William S.; Tardon, Adonina; Rennert, Gad; Chen, Chu; Teare, M. Dawn; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A.; Pesatori, Angela C.; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob S.; Mellemgaard, Anders; Saliba, Walid; Haiman, Christopher; Wilkens, Lynne; Fernandez-Somoano, Ana; Fernandez-Tardon, Guillermo; van der Heijden, Erik H. F. M.; Kim, Jin Hee; Dai, Juncheng; Hu, Zhibin; Davies, Michael P.A.; Marcus, Michael W.; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, Antonia; Tumino, Rosario; Doherty, Jennifer; Goodman, Gary; Cox, Angela; Taylor, Fiona; Woll, Penella; Brüske, Irene; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Albert; Grankvist, Kjell; Johansson, Mikael; Shepherd, Frances; Ming-Sound, Tsao; Arnold, Susanne M.; Haura, Eric B.; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolanta; Mukeria, Anush; Ognjanovic, Simona; Orlowski, Tadeusz M.; Scelo, Ghislaine; Swiatkowska, Beata; Zaridze, David; Bakke, Per S.; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, Eric J.; Butler, Lesley M.; Koh, Woon-Puay; Gao, Yu-Tang; Houlston, Richard; McLaughlin, John; Stevens, Victoria; Nickle, David C.; Obeidat, Ma'en; Timens, Wim; Zhu, Bin; Song, Lei; Artigas, María Soler; Tobin, Martin D.; Wain, Louise V.; Gu, Fangyi; Byun, Jinyoung; Kamal, Ahsan; Zhu, Dakai; Tyndale, Rachel F.; Wei, Wei-Qi; Chanock, Stephen; Brennan, Paul; Amos, Christopher I. (Peer reviewed; Journal article, 2018)

    • Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility 

      Kachuri, Linda; Johansson, Mattias; Rashkin, Sara R.; Graff, Rebecca E.; Bossé, Yohan; Manem, Venkata; Caporaso, Neil E.; Landi, Maria Teresa; Christiani, David C.; Vineis, Paolo; Liu, Geoffrey; Scelo, Ghislaine; Zaridze, David; Shete, Sanjay S.; Albanes, Demetrius; Aldrich, Melinda C.; Tardón, Adonina; Rennert, Gad; Chen, Chu; Goodman, Gary E.; Doherty, Jennifer A.; Bickeboller, Heike; Field, John K.; Davies, Michael P.; Teare, M. Dawn; Kiemeney, Lambertus A.; Bojesen, Stig E.; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Le Marchand, Loïc; Cheng, Iona; Schabath, Matthew B.; Duell, Eric J.; Andrew, Angeline S.; Manjer, Jonas; Lazarus, Philip; Arnold, Susanne; McKay, James D.; Emami, Nima C.; Warkentin, Matthew T.; Brhane, Yonathan; Obeidat, Ma’en; Martin, Richard M.; Relton, Caroline; Smith, George Davey; Haycock, Philip C.; Amos, Christopher I.; Brennan, Paul; Witte, John S.; Hung, Rayjean J. (Peer reviewed; Journal article, 2020)
      Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and ...

    • Mendelian randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers 

      Kachuri, Linda; Saarela, Olli; Bojesen, Stig E.; Smith, George Davey; Liu, Geoffrey; Landi, Maria Teresa; Caporaso, Neil E.; Christiani, David C.; Johansson, Mattias; Panico, Salvatore; Overvad, Kim; Trichopoulou, Antonia; Vineis, Paolo; Scelo, Ghislaine; Zaridze, David; Wu, Xifeng; Albanes, Demetrius; Diergaarde, Brenda; Lagiou, Pagona; Macfarlane, Gary J.; Aldrich, Melinda; Tardon, Adonina; Rennert, Gad; Olshan, Andrew F.; Weissler, Mark C.; Chen, Chu; Goodman, Gary E.; Doherty, Jennifer A.; Ness, Andrew R.; Bickeboller, Heike; Wichmann, H. Erich; Risch, Angela; Field, John K.; Teare, M. Dawn; Kiemeney, Lambertus; van der Heijden, Erik H. F. M.; Carroll, June C.; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Wunsch-Filho, Victor; Tajara, Eloiza H.; Moyses, Raquel Ajub; Nunes, Fabio Daumas; Lam, Stephen; Eluf-Neto, Jose; Lacko, Martin; Peters, Wilbert HM; Le Marchand, Loïc; Duell, Eric J.; Andrew, Angeline S.; Franceschi, Silvia; Schabath, Matthew B.; Manjer, Jonas; Arnold, Susanne; Lazarus, Philip; Mukeriya, Anush; Swiatkowska, Beata; Janout, Vladimir; Holcátová, Ivana; Stojsic, Jelena; Mates, Dana; Lissowska, Jolanta; Boccia, Stefania; Lesseur, Corina; Zong, Xuchen; McKay, James D.; Brennan, Paul; Amos, Christopher I.; Hung, Rayjean J. (Peer reviewed; Journal article, 2018)
      Background: Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck ...

    • Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study 

      Carreras-Torres, Robert; Haycock, Philip C.; Wade, Kaitlin H.; Relton, Caroline L.; Martin, Richard M.; Smith, George Davey; Albanes, Demetrius; Aldrich, Melinda C.; Andrew, Angeline S.; Arnold, Susanne M.; Bickeböller, Heike; Bojesen, Stig E.; Brunnström, Hans; Manjer, Jonas; Brüske, Irene; Caporaso, Neil E.; Chen, Chu; Christiani, David C.; Christian, W. Jay; Doherty, Jennifer A.; Duell, Eric J.; Field, John K.; Davies, Michael P. A.; Marcus, Michael W.; Goodman, Gary E.; Grankvist, Kjell; Haugen, Aage; Hong, Yun-Chul; Kiemeney, Lambertus A.; van der Heijden, Erik H. F. M.; Kraft, Peter; Johansson, Mikael B.; Lam, Stephen; Landi, Maria Teresa; Lazarus, Philip; Le Marchand, Loïc; Liu, Geoffrey; Melander, Olle; Park, Sungshim L.; Rennert, Gad; Risch, Angela; Haura, Eric B.; Scelo, Ghislaine; Zaridze, David; Mukeriya, Anush; Savić, Milan; Lissowska, Jolanta; Swiatkowska, Beata; Janout, Vladimir; Holcatova, Ivana; Mates, Dana; Schabath, Matthew B.; Shen, Hongbing; Tardon, Adonina; Teare, M Dawn; Woll, Penella; Tsao, Ming-Sound; Wu, Xifeng; Yuan, Jian-Min; Hung, Rayjean J.; Amos, Christopher I.; McKay, James; Brennan, Paul (Peer reviewed; Journal article, 2017)
      Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to ...

    • Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci 

      Dai, Juncheng; Li, Zhihua; Amos, Christopher I.; Hung, Rayjean J.; Tardon, Adonina; Andrew, Angeline; Chen, Chu; Christiani, David C.; Albanes, Demetrios; van der Heijden, Erik H. F. M.; Duell, Eric J.; Rennert, Gadi; McKay, James D.; Yuan, Jian-Min; Field, John K.; Manjer, Jonas; Grankvist, Kjell; Le Marchand, Loïc; Teare, Dawn; Schabath, Matthew B.; Aldrich, Melinda C.; Tsao, Ming-Sound; Lazarus, Philip; Lam, Stephen; Bojesen, Stig E.; Arnold, Susanne; Wu, Xifeng; Haugen, Aage; Janout, Vladimir; Johansson, Mikael; Brhane, Yonathan; Fernandez-Somoano, Ana; Kiemeney, Lambertus A.; Davies, Michael; Zienolddiny, Shanbeh; Hu, Zhibin; Shen, Hongbing (Peer reviewed; Journal article, 2019)
      DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in ...