dc.contributor.author | Hadrup, Niels | |
dc.contributor.author | Saber, Anne T. | |
dc.contributor.author | Kyjovska, Zdenka O. | |
dc.contributor.author | Jacobsen, Nicklas R. | |
dc.contributor.author | Vippola, Minnamari | |
dc.contributor.author | Sarlin, Essi | |
dc.contributor.author | Ding, Yaobo | |
dc.contributor.author | Schmid, Otmar | |
dc.contributor.author | Wallin, Håkan | |
dc.contributor.author | Jensen, Keld A. | |
dc.contributor.author | Vogel, Ulla | |
dc.date.accessioned | 2024-08-21T10:53:55Z | |
dc.date.available | 2024-08-21T10:53:55Z | |
dc.date.created | 2020-01-13T10:10:22Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1382-6689 | |
dc.identifier.uri | https://hdl.handle.net/11250/3147356 | |
dc.description.abstract | Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials. | |
dc.description.abstract | Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials. Inflammation and DNA strand breaks | |
dc.language.iso | eng | |
dc.title | Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials. Inflammation and DNA strand breaks | |
dc.title.alternative | Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials. Inflammation and DNA strand breaks | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | |
dc.source.volume | 74 | |
dc.source.journal | Environmental Toxicology and Pharmacology | |
dc.identifier.doi | 10.1016/j.etap.2019.103303 | |
dc.identifier.cristin | 1771104 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |